Outcomes of corneal neurotisation using processed nerve allografts: a multicentre case series
| Autor: | Christopher Weller, Adam R. Sweeney, Bradford W. Lee, Margaret Y. Wang, Cat N. Burkat, Andrea L. Kossler, Michael T. Yen |
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| Rok vydání: | 2020 |
| Předmět: |
Corneal sensation
medicine.medical_specialty Ocular trauma Corneal Diseases Cornea 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Trigeminal nerve palsy medicine Humans 030223 otorhinolaryngology Neurotrophic keratopathy Nerve Transfer Retrospective Studies Best corrected visual acuity Corneal Dystrophies Hereditary Corneal anaesthesia business.industry Allografts Sensory Systems Surgery Ophthalmology medicine.anatomical_structure Trigeminal Nerve Diseases 030221 ophthalmology & optometry Cadaveric spasm business |
| Zdroj: | The British journal of ophthalmology. 106(3) |
| ISSN: | 1468-2079 |
| Popis: | BackgroundCorneal neurotisation is a rapidly evolving procedure treating neurotrophic keratopathy. The variety of surgical techniques used and corresponding outcomes after corneal neurotisation are not well understood. This study describes the techniques and outcomes in the largest case series of corneal neurotisation using processed nerve allografts to date.MethodsThis is a retrospective case series of patients who underwent corneal neurotisation with human cadaveric processed nerve allografts. All patients had preoperative and postoperative description of best corrected visual acuity and measurement of corneal sensation. Comparative studies after stratification of techniques were performed.ResultsA total of 17 patients were identified. The cause of corneal anaesthesia was prior infection in eight cases, trigeminal nerve palsy in eight cases and ocular trauma in one case. There were no intraoperative or postoperative complications. Following neurotisation surgery, the time to first gain of corneal sensation and maximal gain of sensation occurred at a mean of 3.7 months (range 1–8 months) and 6.6 months (range 3–15 months), respectively. The mean preoperative and postoperative corneal sensation as measured by Cochet-Bonnet aesthesiometry was 0.36 cm (range 0–3.2 cm) and 4.42 cm (range 0–6 cm), respectively (pConclusionCorneal neurotisation with processed nerve allografts is a safe and effective procedure. This study provides further evidence for the use of processed nerve allografts for corneal neurotisation. |
| Databáze: | OpenAIRE |
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