Insights into the effects of diclofenac and other non-steroidal anti-inflammatory agents on ion channels
| Autor: | Asfree Gwanyanya, Kanigula Mubagwa, Regina Macianskiene |
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| Rok vydání: | 2012 |
| Předmět: |
Drug
Diclofenac media_common.quotation_subject Pain Pharmaceutical Science Inflammation Pharmacology Ion Channels Transient receptor potential channel non-steroidal anti-inflammatory drug medicine Animals Humans Drug Interactions Ion channel media_common Chemistry Anti-Inflammatory Agents Non-Steroidal Antagonist Drug Synergism diclofenac Drug Design ion channel Second messenger system Chloride channel medicine.symptom medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 64:1359-1375 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.2012.01479.x |
| Popis: | Objectives Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of inflammation and pain. Most effects of NSAIDs are attributed to the inhibition of cyclooxygenases (COX). However, many NSAIDs may have other effects not related to COX, including the modulation of various ion channels. The clinical implications of the effects on channels are not fully understood. This review outlines the effects of NSAIDs, with special attention to diclofenac, on ion channels and highlights the possible underlying mechanisms. Key findings NSAIDs have effects on channels such as inhibition, activation or changes in expression patterns. The channels affected include voltage-gated Na+, Ca2+, or K+ channels, ligand-gated K+ channels, transient receptor potential and other cation channels as well as chloride channels in several types of cells. The mechanisms of drug actions not related to COX inhibition may involve drug–channel interactions, interference with the generation of second messengers, changes in channel expression, or synergistic/antagonist interactions with other channel modulators. Summary The effects on ion channels may account for novel therapeutic actions of NSAIDs or for adverse effects. Among the NSAIDs, diclofenac may serve as a template for developing new channel modulators and as a tool for investigating the actions of other drugs. |
| Databáze: | OpenAIRE |
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