Carcinoma of unknown primary abuts left clavicle: Case report and review of the literature
| Autor: | Sofoklis Mitsos, Savvas Lampridis, Martin Hayward, Marco Scarci, Georgios Geropoulos, Nikolaos Panagiotopoulos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Rib cage Left clavicle medicine.diagnostic_test business.industry Neck mass Soft tissue medicine.disease Article Carcinoma of unknown primary 03 medical and health sciences Thoracic surgery 0302 clinical medicine Cardiothoracic surgery 030220 oncology & carcinogenesis Biopsy Case report medicine Unknown primary Carcinoma 030211 gastroenterology & hepatology Surgery Radiology medicine.symptom business |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| Popis: | Highlights • Carcinoma of unknown primary clinical manifestations usually associated with head and neck region. • Painless cervical Lymphadenopathy is the most common symptom of the disease. • Laboratory tests usually do not identify the primary disease. • Limited data exists about management and the role of surgery in carcinoma of unknown primary if a single neck mass exists without evidence of lymph node implication. Introduction Carcinoma of unknown primary is a well-recognized clinical syndrome which accounts for the 3–5% of all the malignancies. Patients with carcinoma of unknown primary usually present with late stage disease without having identified the primary source of the tumour despite an extensive diagnostic work-up. Presentation of case A 60 years old male presented to the clinic complaining of a neck mass to the left lateral neck. Patient’s history was unremarkable without evidence of any malignant disease. Clinical and radiological examination revealed a cystic mass extending from the lower one third of the neck to the left clavicle causing periostal reaction. Mass biopsy and PET-CT was unspecific for the primary origin of the mass. However in the context of tumour immunohistochemistry, HPV status, neck location and basaloid cell differentiation, the tumour mass was considered as carcinoma of unknown primary with possible oropharyngeal primary location. The patient underwent surgical resection of the mass, left clavicle and the first rib. One year after the operation the patient is disease free. Discussion Although CUP usually presents with cervical lyphadenopathy, in our case there was no evidence of lymph node tissue infiltration in the neck region. Surgical resection of the mass showed that the location was extending within the cervical soft tissues and upper thorax. Taking into consideration the absence of lymphadenopathy this is an uncommon location of carcinoma of unknown primary in the neck. Conclusion This is an uncommon location of CUP with possible implications in survival and management. |
| Databáze: | OpenAIRE |
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