Efficacy of exogenous atrial natriuretic peptide in patients with heart failure with preserved ejection fraction: deficiency of atrial natriuretic peptide and replacement therapy

Autor: Yuji Ikari, Makoto Natsumeda, Masaaki Konishi, Norihito Nakamura, Shunsuke Ishii, Katsuaki Sakai, Takanori Ikeda, Tsutomu Murakami, Keisuke Kida, Shingo Matsumoto, Gaku Nakazawa, Atsushi Shibata, Yohei Ohno, Mai Ishihara, Takayuki Kabuki
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
medicine.medical_treatment
Atrial fibrillation (AF)
030204 cardiovascular system & hematology
Acute heart failure (AHF)
Carperitide
03 medical and health sciences
0302 clinical medicine
Atrial natriuretic peptide
Internal medicine
Original Research Articles
Medicine
Diseases of the circulatory (Cardiovascular) system
In patient
030212 general & internal medicine
Original Research Article
Ejection fraction
business.industry
Differential regulation
Brain natriuretic peptide (BNP)
Brain natriuretic peptide
medicine.disease
Heart failure
RC666-701
Cardiology
cardiovascular system
Diuretic
Cardiology and Cardiovascular Medicine
Heart failure with preserved ejection fraction
business
hormones
hormone substitutes
and hormone antagonists
Left atrial dysfunction
circulatory and respiratory physiology
Zdroj: ESC Heart Failure, Vol 7, Iss 6, Pp 4172-4181 (2020)
ESC Heart Failure
ISSN: 2055-5822
Popis: Aims Exogenous atrial natriuretic peptide (ANP) may be a logical treatment for heart failure (HF) patients with ANP deficiency. Lower ANP concentrations may result from HF with preserved ejection fraction (HFpEF), which also results in lower brain natriuretic peptide levels in HFpEF relative to HF with reduced ejection fraction (HFrEF), although clinical features regarding circulating ANP in HFpEF and HFrEF have not been fully investigated during acute HF. Here, we characterized the differential regulation of circulating ANP and the efficacy of exogenous ANP (carperitide) in patients with acute HF, especially HFpEF. Methods and results Serum ANP levels before treatment and the diuretic effect of 0.0125 μg/kg/min of carperitide alone for the first 6 h were prospectively evaluated in 113 patients with acute HF who were divided into two groups: HFpEF vs. HFrEF. We mainly analysed the impact of baseline ANP levels and the presence of HFpEF on the diuretic effect of exogenous ANP. There was an inverse relationship between ANP levels and the diuretic effect of exogenous ANP (r 2 = 0.19, P
Databáze: OpenAIRE
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