Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells
| Autor: | Stephen C. Jameson, Leo Lefrançois, Kimberly S. Schluns, Michelle M. Sandau |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_treatment
Immunology Population Epitopes T-Lymphocyte Bone Marrow Cells Mice Transgenic Biology CD8-Positive T-Lymphocytes Mice Cross-Priming Lymphopenia medicine Bystander effect Immunology and Allergy Cytotoxic T cell Animals Homeostasis IL-2 receptor education Cells Cultured Interleukin-15 Mice Knockout education.field_of_study Receptors Interleukin-15 Models Immunological Cell Differentiation Receptors Interleukin-2 Phenotype Cell biology Killer Cells Natural Mice Inbred C57BL Protein Subunits Cytokine medicine.anatomical_structure Interleukin 15 Radiation Chimera Bone marrow Immunologic Memory |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 173(11) |
| ISSN: | 0022-1767 |
| Popis: | IL-15 is critical for generation of multiple lymphoid subsets. Recent data have demonstrated a unique aspect of responses to IL-15, in that cells bearing the IL-15Rα chain can bind soluble IL-15 and “transpresent” the cytokine to other cells, allowing the latter to respond to IL-15. However, it is unclear whether IL-15 is normally secreted and then becomes bound to surface IL-15Rα on bystander cells, or whether transpresentation is mediated by the same cells which synthesize IL-15. Using mixed bone marrow chimeric mice, we present evidence for the latter model, showing that development of NK cells and memory phenotype CD8 T cells necessitates that both IL-15 and IL-15Rα be expressed by the same population of cells. These data argue that soluble forms of IL-15 are irrelevant for physiological responses to this cytokine, and the implications of this finding are discussed. |
| Databáze: | OpenAIRE |
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