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Tofan N. V., Iablonska V. B., Khyzhnyak O. V., Nigreskul O. Yu., Novikov S. A. Efficacy of pharmacotherapy according to laser correlation spectrometry in elderly with arterial hypertension and comorbid pathology. Journal of Education, Health and Sport. 2019;9(5):595-601. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3241770 http://ojs.ukw.edu.pl/index.php/johs/article/view/7015 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 29.04.2019. Revised: 15.05.2019. Accepted: 31.05.2019. EFFICACY OF PHARMACOTHERAPY ACCORDING TO LASER CORRELATION SPECTROMETRY IN ELDERLY WITH ARTERIAL HYPERTENSION AND COMORBID PATHOLOGY N. V. Tofan, V. B. Iablonska, O. V. Khyzhnyak, O. Yu. Nigreskul, S. A. Novikov Odessa National Medical University – Odessa, Ukraine Internal Medicine Department №2 Abstract In patients with arterial hypertension (AH) pharmacotherapy often remains ineffective because of comorbid pathology. Research of haemodynamic and homeostatic processes in such patients allows prescribe effective antihypertensive medicines, improve life quality and prognosis. Material and methods: 60 patients with AH, coronary artery disease and obesity were divided into three groups: 1st group was treated with lisinopril + atorvastatin + aspirin (regimen I); 2nd group was treated with lisinopril + atorvastatin + bisoprolol + aspirin (regimen II); 3rd group was treated with lisinopril + bisoprolol + indapamide + atorvastatin + aspirin (regimen III). Laser correlation spectrometry (LCS) was used to evaluate the homeostatic alterations. Results: All regimens were equally effective in normalization of systolic blood pressure and did not influence the ejection fraction. Only in the 3rd group was determined significant increase of glomerular filtration rate (92.73±2.12 vs 79.62±13.62 ml/min/1.73m2). The LCS test showed that these patients had high level of light scattering particles IV, which may be caused by activation of anabolic processes. In other groups, spectral alterations were not so expressive. Conclusions: Prescription of antihypertensive therapy cause homeostatic and metabolic alterations, which may influence the efficacy of treatment. Keywords: pharmacotherapy, comorbid pathology, laser correlation spectrometry. |
