Association between cardiovascular risk factors and degenerative disc disease of the thoracolumbar spine in the general population: results from the KORA MRI Study
| Autor: | Annette Peters, Roberto Lorbeer, Christopher L. Schlett, Mike Notohamiprodjo, Fabian Bamberg, Konstantin Nikolaou, Christian Klinger, Elke Maurer, Gerald Hefferman, Sven S. Walter |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Cardiovascular risk factors Population Intervertebral Disc Degeneration Degenerative disc disease 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Whole Body Imaging Radiology Nuclear Medicine and imaging education Aged 030222 orthopedics education.field_of_study Lumbar Vertebrae Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Thoracolumbar spine Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Cross-Sectional Studies Cardiovascular Diseases Heart Disease Risk Factors Hypertension Disc degeneration Female business Intervertebral Disc Displacement 030217 neurology & neurosurgery |
| Zdroj: | Acta Radiologica. 63:750-759 |
| ISSN: | 1600-0455 0284-1851 |
| Popis: | Background Little is known about the associations between cardiovascular risk factors (CRF) and disc degeneration (DD). Purpose To evaluate the potential association between CRFs and intervertebral DD in a population-based sample. Methods A total of 400 participants from the community-based KORA-study were assessed in terms of CRFs, specifically obesity, hypertension, diabetes, elevated LDL-c, low HDL-c, elevated triglycerides, smoking status, and alcohol consumption. The patients additionally underwent whole-body magnetic resonance imaging (MRI) using T2-weighted single-shot fast-spin-echo and T1 dual-echo gradient-echo Dixon pulse sequences. Thoracic and lumbar DD were assessed using the Pfirrmann score and for the presence of disc bulging/protrusion. Cross-sectional associations between CRFs and MR-based Pfirrmann score were then analyzed. Results A total of 385 individuals (58.2% men; mean age 56.3 ± 9.2 years) were included. Prevalence of DD was 76.4%. Older age (β = 0.18; 95% CI 0.12–0.25; P Conclusion A significant independent association exists between age, BMI, and intervertebral DD. In contrast, there is no significant association between cardiovascular risk factors and DD. Providing strong evidence that the pathologic process undergirding DD is mechanical, rather than microvascular, in nature. |
| Databáze: | OpenAIRE |
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