Association of Coronary Artery Stenosis with Carotid Atherosclerosis in Asymptomatic Type 2 Diabetic Patients
| Autor: | Takahiro Okusu, Fumiyo Kubo, Yuichi Yamamoto, Ken’ya Sakamoto, Toshikazu Kashiyama, Takashi Katura, Yasunori Ueda, Naoto Katakami, Yutaka Umayahara, Hideaki Kaneto, Keisuke Kosugi, Yoko Irie |
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| Rok vydání: | 2011 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty Type 2 diabetes Logistic regression Asymptomatic Coronary artery disease Risk Factors Internal medicine Internal Medicine medicine Humans Aged Ultrasonography business.industry Surrogate endpoint Biochemistry (medical) Ultrasound Coronary Stenosis Area under the curve Middle Aged medicine.disease Radiography Cross-Sectional Studies Diabetes Mellitus Type 2 ROC Curve cardiovascular system Cardiology Female medicine.symptom Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business Dyslipidemia |
| Zdroj: | Journal of Atherosclerosis and Thrombosis. 18:337-344 |
| ISSN: | 1880-3873 1340-3478 |
| DOI: | 10.5551/jat.6049 |
| Popis: | Aims: Carotid atherosclerosis assessed by ultrasound is an established surrogate marker for systemic atherosclerosis. This study aimed to evaluate the association between coronary artery stenosis assessed by coronary computed tomography angiography (CCTA) and intima-media thickness (IMT) in asymptomatic type 2 diabetic patients.Methods: In a cross-sectional study, carotid IMT was measured by ultrasound and CCTA in 169 asymptomatic type 2 diabetic patients.Results: Among 169 patients, 77 (46%) had coronary artery stenosis on CCTA. Multivariate logistic regression analysis revealed four independent predictors of coronary artery stenosis: diabetes duration (OR 4.07, 95%CI 2.34-7.12; p< 0.001), gender (OR 1.66, 95% CI 1.05-2.61; p=0.029), dyslipidemia (OR 2.07, 95%CI 1.34-3.18; p=0.001), and max-IMT (OR 2.71, 95%CI 1.70-4.33; p< 0.001). By ROC curve analyses, the area under the curve (AUC) for max-IMT was 0.73 (95%CI 0.66-0.81; p< 0.001) and mean-IMT was 0.64 (95%CI 0.56-0.73; p=0.001). The cut-off level for the greatest sensitivity and specificity for max-IMT was 1.55 mm (sensitivity 0.90, specificity 0.46), and mean-IMT was 1.05 mm (sensitivity 0.55, specificity 0.72).Conclusion: Carotid IMT was associated with coronary artery stenosis assessed by CCTA in asymptomatic type 2 diabetic patients. Measurement of both mean- and max-carotid IMT is useful for selecting asymptomatic type 2 diabetic patients who should undergo CCTA screening. |
| Databáze: | OpenAIRE |
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