Application of magnifying narrow-band imaging endoscopy for diagnosis of early gastric cancer and precancerous lesion
Autor: | Shi-Bin Guo, Jing Zhang, Zhi-Jun Duan |
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Jazyk: | angličtina |
Rok vydání: | 2011 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Gastroenterology Sensitivity and Specificity Young Adult Stomach Neoplasms Internal medicine Biopsy Gastroscopy medicine Humans lcsh:RC799-869 Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Stomach Carcinoma in situ Cancer General Medicine Middle Aged medicine.disease Endoscopy Early Gastric Cancer medicine.anatomical_structure Early Diagnosis Gastric pits High Grade Intraepithelial Neoplasia lcsh:Diseases of the digestive system. Gastroenterology Female business Precancerous Conditions Carcinoma in Situ Research Article |
Zdroj: | BMC Gastroenterology BMC Gastroenterology, Vol 11, Iss 1, p 135 (2011) |
ISSN: | 1471-230X |
Popis: | Background Gastric carcinoma is the second commonest cause of cancer deaths worldwide. Early detection and diagnosis of gastric cancer in the stomach is important for improving the prognosis of gastric cancer. This retrospective study was designed to investigate the value of magnifying narrow-band imaging (NBI) in the diagnosis of precancerous lesions and early gastric cancer. Methods This study included 122 patients who were diagnosed with early gastric cancer or precancerous gastric lesions by endoscopy. The patients underwent an examination with conventional endoscopy, magnifying NBI, and magnifying chromoendoscopy. Images resolution was evaluated, and the morphology, pit patterns and blood capillary forms of lesions were analyzed. The presence of gastric carcinoma and high grade intraepithelial neoplasia in the biopsy samples was considered as a positive pathological result, which is used to assess accuracy of endoscopic diagnosis. Results For image resolution, magnifying NBI and magnifying chromoendoscopy were significantly superior to magnifying conventional endoscopy in morphology, pit pattern and blood capillary form (P < 0.01), and magnifying NBI was significantly superior to magnifying chromoendoscopy in blood capillary form (P < 0.01). IV, V1, and VI type of gastric pit pattern were detected in 14 cases, 43 cases, and 17 cases in patients with high grade intraepithelial neoplasia, respectively. V1 and VI type of gastric pit pattern were detected in 9 cases and 39 cases in patients with early gastric cancer, respectively. The presence of irregular minute vessels and variation in the caliber of vessels was found in 109 cases. The accuracy, sensitivity, specificity, false positive rate and false negative rate for diagnosis of early gastric cancer and precancerous gastric lesions were 68.9%, 95.1%, 63.1%, 24.5%, and 32.4% for conventional endoscopy, 93.6%, 92.7%, 94.5%, 5.7%, and 6.9% for magnifying NBI, and 91.3%, 88.6%, 93.2%, 13.2%, and 21.48% for magnifying chromoendoscopy, respectively. Conclusions This study demonstrates that magnifying NBI is superior to conventional endoscopy in the diagnosis of early gastric cancer and precancerous gastric lesions, and can be used for screening early malignancies of the stomach. |
Databáze: | OpenAIRE |
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