Baicalin Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice
| Autor: | Huei-Hsuan Cheng, Yi-Ting Chen, Chen Chen Lee, Jiunn-Wang Liao, Ya-Wen Chao, Chien-Hui Hung, Chien-Neng Wang, Jia Liang Jiang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Erythema Pharmaceutical Science Imiquimod Inflammation Pharmacology Analytical Chemistry Mice 03 medical and health sciences chemistry.chemical_compound Psoriasis Drug Discovery medicine Animals Humans Skin Flavonoids Mice Inbred BALB C integumentary system biology business.industry Anti-Inflammatory Agents Non-Steroidal Interleukin-17 Organic Chemistry Receptors Interleukin medicine.disease biology.organism_classification Disease Models Animal 030104 developmental biology Complementary and alternative medicine chemistry Aminoquinolines Cytokines Molecular Medicine Scutellaria baicalensis Female Tumor necrosis factor alpha Drug Eruptions Interleukin 17 medicine.symptom business Baicalin medicine.drug |
| Zdroj: | Planta Medica. 84:1110-1117 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | Baicalin is the main flavonoid from the roots of an important medicinal plant, Scutellaria baicalensis, which shows a variety biological activities. Psoriasis is a chronic immune-mediated inflammatory disease that affects the skin. The unmet need of psoriasis is that many patients do not respond adequately to available clinical treatment. In this study, we found that baicalin showed inhibited dermal inflammation in a murine model of psoriasis via topical application of imiquimod. After a 5-day topical imiquimod application, baicalin or the control vehicle cream was to applied to the lesions of BALB/c mice for a further 4 days. The erythema, scaling, and thickness of the epidermal layer significantly improved in the baicalin-treated mice. The levels of interleukin-17A, interleukin-22, interleukin-23, and tumor necrosis factor in the skin significantly decreased after baicalin treatment. Baicalin also inhibited imiquimod-induced interleukin-17A production in skin draining lymph node cells. The infiltration of γδ T cells into the skin lesions induced by imiquimod was also suppressed after baicalin treatment. These results suggest that baicalin inhibited skin inflammation through the inhibition of the interleukin-17/interleukin-23 axis in a murine model of psoriasis. |
| Databáze: | OpenAIRE |
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