Is there an oxidative cost of acute stress? Characterization, implication of glucocorticoids and modulation by prior stress experience
| Autor: | Alexis D. Ziur, Chelsea P. Fischer, Antoine Stier, Wendy L. Reed, Ryan T. Paitz, Olivia M. Seecof, Vince J. Fasanello, Sarah Gronsky, Ariana Majer, Kailey Tindle, Brian J. Frenz, Kelsey L. Fletcher, Mark F. Haussmann, Brian G. Vassallo |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
medicine.medical_specialty glucocorticoid-induced oxidative stress bird Oxidative phosphorylation Coturnix medicine.disease_cause 010603 evolutionary biology 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound Random Allocation Corticosterone hormesis Internal medicine biology.animal medicine Ingestion Animals Glucocorticoids 030304 developmental biology General Environmental Science 0303 health sciences General Immunology and Microbiology biology Ecology business.industry corticosterone Stressor Hormesis General Medicine Quail Hormones Oxidative Stress Endocrinology chemistry Female General Agricultural and Biological Sciences business Oxidative stress Glucocorticoid Stress Psychological medicine.drug Research Article |
| Zdroj: | Proceedings of the Royal Society B: Biological Sciences |
| ISSN: | 1471-2954 0962-8452 |
| Popis: | Acute rises in glucocorticoid hormones allow individuals to adaptively respond to environmental challenges but may also have negative consequences, including oxidative stress. While the effects of chronic glucocorticoid exposure on oxidative stress have been well characterized, those of acute stress or glucocorticoid exposure have mostly been overlooked. We examined the relationship between acute stress exposure, glucocorticoids and oxidative stress in Japanese quail ( Coturnix japonica ). We (i) characterized the pattern of oxidative stress during an acute stressor in two phenotypically distinct breeds; (ii) determined whether corticosterone ingestion, in the absence of acute stress, increased oxidative stress, which we call glucocorticoid-induced oxidative stress (GiOS); and (iii) explored how prior experience to stressful events affected GiOS. Both breeds exhibited an increase in oxidative stress in response to an acute stressor. Importantly, in the absence of acute stress, ingesting corticosterone caused an acute rise in plasma corticosterone and oxidative stress. Lastly, birds exposed to no previous acute stress or numerous stressful events had high levels of GiOS in response to acute stress, while birds with moderate prior exposure did not. Together, these findings suggest that an acute stress response results in GiOS, but prior experience to stressors may modulate that oxidative cost. |
| Databáze: | OpenAIRE |
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