Principles and practice of designing microbial biocatalysts for fuel and chemical production
| Autor: | Lonnie O. Ingram, Keelnatham T. Shanmugam |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Ethanol
business.industry Butanol Fossil fuel food and beverages Lignocellulosic biomass Bioengineering Applied Microbiology and Biotechnology Microbial Physiology Renewable energy Metabolic engineering chemistry.chemical_compound chemistry Cellulosic ethanol Biofuel Biofuels Fermentation Escherichia coli Environmental science Biomass Biochemical engineering business Hexoses Biotechnology |
| Zdroj: | Journal of Industrial Microbiology and Biotechnology. 49 |
| ISSN: | 1476-5535 1367-5435 |
| Popis: | The finite nature of fossil fuels and the environmental impact of its use have raised interest in alternate renewable energy sources. Specifically, nonfood carbohydrates, such as lignocellulosic biomass, can be used to produce next generation biofuels, including cellulosic ethanol and other nonethanol fuels like butanol. However, currently there is no native microorganism that can ferment all lignocellulosic sugars to fuel molecules. Thus, research is focused on engineering improved microbial biocatalysts for production of liquid fuels at high productivity, titer, and yield. A clear understanding and application of the basic principles of microbial physiology and biochemistry are crucial to achieve this goal. In this review, we present and discuss the construction of microbial biocatalysts that integrate these principles with ethanol-producing Escherichia coli as an example of metabolic engineering. These principles also apply to fermentation of lignocellulosic sugars to other chemicals that are currently produced from petroleum. |
| Databáze: | OpenAIRE |
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