Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography–mass spectrometry

Autor:	Manabu Okumura, Akiyo Sakushima, Mitsuko Yamada, Muneaki Hidaka, Eri Shimizu, Kazuhiko Arimori, Shinzo Hosoi
Rok vydání:	2008
Předmět:	CYP3A Trimer In Vitro Techniques Mass spectrometry Inhibitory postsynaptic potential Catechin Mass Spectrometry Averrhoa carambola Magnoliopsida chemistry.chemical_compound Liquid chromatography–mass spectrometry Biflavonoids Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Humans Proanthocyanidins Procyanidin B1 Chromatography biology Plant Extracts Chemistry Stereoisomerism biology.organism_classification Fruit Microsomes Liver Molecular Medicine Chromatography Liquid
Zdroj:	Journal of Natural Medicines. 62:345-348
ISSN:	1861-0293 1340-3443
Popis:	In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography-mass spectrometry (LC-MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory components.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78ac705ebe193d08d8b76ec6ad1b40d https://doi.org/10.1007/s11418-008-0239-y Zobrazit plný text záznamu Full text from SpringerLink