Biological properties and therapeutic effects of plant-derived nanovesicles
| Autor: | Niamat Hossain, Massimo Conese, Sante Di Gioia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Small interfering RNA media_common.quotation_subject mirnas Inflammation Review Pharmacology 03 medical and health sciences 0302 clinical medicine inflammatory bowel disease Medicine Internalization media_common business.industry food and beverages General Medicine Small molecule exosome-like nanoparticles 030104 developmental biology 030220 oncology & carcinogenesis drug delivery Drug delivery Toxicity antitumoral Nucleic acid medicine.symptom business Drug carrier |
| Zdroj: | Open Medicine, Vol 15, Iss 1, Pp 1096-1122 (2020) Open Medicine |
| ISSN: | 2391-5463 |
| Popis: | Exosomes-like nanoparticles can be released by a variety of plants and vegetables. The relevance of plant-derived nanovesicles (PDNVs) in interspecies communication is derived from their content in biomolecules (lipids, proteins, and miRNAs), absence of toxicity, easy internalization by mammalian cells, as well as for their anti-inflammatory, immunomodulatory, and regenerative properties. Due to these interesting features, we review here their potential application in the treatment of inflammatory bowel disease (IBD), liver diseases, and cancer as well as their potentiality as drug carriers. Current evidence indicate that PDNVs can improve the disease state at the level of intestine in IBD mouse models by affecting inflammation and promoting prohealing effects. While few reports suggest that anticancer effects can be derived from antiproliferative and immunomodulatory properties of PDNVs, other studies have shown that PDNVs can be used as effective delivery systems for small molecule agents and nucleic acids with therapeutic effects (siRNAs, miRNAs, and DNAs). Finally, since PDNVs are characterized by a proven stability in the gastrointestinal tract, they have been considered as promising delivery systems for natural products contained therein and drugs (including nucleic acids) via the oral route. |
| Databáze: | OpenAIRE |
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