Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice
| Autor: | Yinghua Liu, Wei Wei, Narjes Baazaoui, Fei Liu, Khalid Iqbal |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
retina Aging Pathology medicine.medical_specialty genetic structures prevention of AMD Cognitive Neuroscience Microgliosis lcsh:RC321-571 Lipofuscin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Atrophy 3xTg-mice medicine neurotrophic peptidergic compound P021 lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry age-related macular degeneration Original Research Retina Retinal pigment epithelium business.industry Retinal Macular degeneration aged rats medicine.disease eye diseases Astrogliosis 030104 developmental biology medicine.anatomical_structure chemistry sense organs business Alzheimer’s disease 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 11 (2019) |
| ISSN: | 1663-4365 |
| Popis: | Age-associated macular degeneration (AMD), which leads to loss of vision at its end stage, is one of the most common neurodegenerative diseases among the elderly. However, to date, no effective drug therapy is available for the prevention of AMD. Here, we report the occurrence of AMD pathology and its prevention by chronic treatment with the neurotrophic peptidergic compound P021, in aged rats and 3xTg-AD mice. We found photoreceptor degeneration, lipofuscin granules, vacuoles, and atrophy in retinal pigment epithelium (RPE) as well as Bruch’s membrane (BM) thickening; in aged rats, we even found rosette-like structure formation. Microgliosis and astrogliosis were observed in different retinal layers. In addition, we also found that total tau, phosphorylated tau, Aβ/APP, and VEGF were widely distributed in the sub-retina of aged rats and 3xTg mice. Importantly, chronic treatment with P021 for 3 months in rats and for 18 months in 3xTg mice ameliorated the pathological changes above. These findings indicate the therapeutic potential of P021 for prevention and treatment of AMD and retinal changes associated with aging and Alzheimer’s disease. |
| Databáze: | OpenAIRE |
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