Long-Term Follow-Up of Antibody Titers Against Measles, Mumps, and Rubella in Recipients of Allogenic Hematopoietic Cell Transplantation
Autor: | Urs Schanz, Jan Bögeholz, Antonia M.S. Müller, Norman F. Russkamp, Eugenia Haralambieva, Elise Gourri, C. M. Wilk, Markus G. Manz, Nicolas J. Mueller |
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Přispěvatelé: | University of Zurich, Müller, Antonia M S |
Rok vydání: | 2020 |
Předmět: |
2747 Transplantation
2720 Hematology 610 Medicine & health Antibodies Viral Rubella Measles 10234 Clinic for Infectious Diseases 03 medical and health sciences 0302 clinical medicine Immunity 10049 Institute of Pathology and Molecular Pathology Humans Medicine Mumps Retrospective Studies Transplantation biology business.industry Hematopoietic Stem Cell Transplantation Antibody titer Hematology medicine.disease Vaccination 030220 oncology & carcinogenesis 10032 Clinic for Oncology and Hematology Humoral immunity Immunology biology.protein Antibody business Measles-Mumps-Rubella Vaccine Follow-Up Studies 030215 immunology |
Zdroj: | Biology of Blood and Marrow Transplantation. 26:581-592 |
ISSN: | 1083-8791 |
Popis: | Outbreaks of viral infections, such as measles, are regularly observed and pose a serious threat to recipients of allogeneic hematopoietic cell transplantation (HCT). The questions of how long cellular and humoral protective host immunity persists, and whether donor immunity can be transferred has not been clarified. Here we present a retrospective analysis of humoral immunity—serial antibody titers against measles, mumps, and rubella—in 331 patients who underwent allogeneic HCT at our single center between 2002 and 2015. Associations between the loss of protective antibody levels and clinical patient characteristics and transplantation parameters were examined. In general, antibody protection against measles persisted longer, with 72% of patients maintaining sufficient titers at 5 years post-HCT even without revaccination, while at that time only 65% and 50% of patients had protective immunity against rubella and mumps, respectively. The great majority of donors were seropositive for all 3 viruses; however, it appeared that donor humoral immunity could not be transferred and had no impact on post-HCT serostatus. Rather, the most relevant factor for persistent protective antibody titers against measles and rubella was whether patients were born before the introduction of the respective vaccine and thus were immunized by the wild-type disease-inducing virus instead of the vaccine. Moreover, the presence of moderate and severe chronic graft-versus-host disease (GVHD) was associated with more rapid loss of immune protection. In contrast, underlying disease, intensity of the conditioning regimen, use of antithymocyte globulin, age, and graft source had no influence on antibody titers. Overall, our findings suggest that the majority of antibodies against measles, mumps, and rubella originate from residual host cells, whereas donor immune status appears to have no influence on antibody protection post-HCT. |
Databáze: | OpenAIRE |
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