The household contact study design for genetic epidemiological studies of infectious diseases
| Autor: | LaShaunda L. Malone, Ezekiel Mupere, Noemi B. Hall, Catherine M. Stein |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Household contact lcsh:QH426-470 Population Biology complex traits 03 medical and health sciences Environmental health Epidemiology cohort study Genetics medicine Sequencing whole genome studies Gene–environment interaction extended pedigrees education Genetics (clinical) 030304 developmental biology Genetic association 0303 health sciences education.field_of_study Clinical study design 030305 genetics & heredity 3. Good health lcsh:Genetics Statistical genetics Perspective Article Molecular Medicine case-contact Cohort study |
| Zdroj: | Frontiers in Genetics, Vol 4 (2013) Frontiers in Genetics |
| ISSN: | 1664-8021 |
| DOI: | 10.3389/fgene.2013.00061 |
| Popis: | Most genetic epidemiological study designs fall into one of two categories: family-based and population-based (case-control). However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies. |
| Databáze: | OpenAIRE |
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