A clinically realistic large animal model of intra-articular fracture that progresses to post-traumatic osteoarthritis
| Autor: | E. Swanson, Yuki Tochigi, M.J. Rudert, Douglas C. Fredericks, James A. Martin, N. Roberts, Emily B Petersen, Thomas E. Baer, Jessica E. Goetz |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Intra-Articular Fractures Swine Post-traumatic osteoarthritis medicine.medical_treatment Radiography Biomedical Engineering Osteoarthritis Closed Fracture Fracture Fixation Internal Yucatan minipig Rheumatology medicine Synovial fluid Internal fixation Animals Orthopedics and Sports Medicine Ankle Injuries Reduction (orthopedic surgery) Intra-articular fracture business.industry Post traumatic osteoarthritis medicine.disease Surgery Tibial Fractures Disease Models Animal Swine Miniature Closed fracture business Ankle Joint Large animal |
| Zdroj: | Osteoarthritis and Cartilage. 23(10):1797-1805 |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2015.05.022 |
| Popis: | SummaryObjectiveTranslation of promising treatments for post-traumatic osteoarthritis (PTOA) to patients with intra-articular fracture (IAF) has been limited by the lack of a realistic large animal model. To address this issue we developed a large animal model of IAF in the distal tibia of Yucatan minipigs and documented the natural progression of this injury.DesignTwenty-two fractures were treated using open reduction and internal fixation with either an anatomic reduction or an intentional 2-mm step-off. Pre-operatively, and 3 days, 1, 2, 4, 8, and 12 weeks post-operatively, animals were sedated for synovial fluid draws and radiographs. Limb loading was monitored at the same time points using a Tekscan Walkway. Animals were sacrificed at 12 weeks and the limbs were harvested for histological evaluation.ResultsAll animals achieved bony union by 12 weeks, facilitating nearly complete recovery of the initial 60% decrease in limb loading. TNFα, IL1β, IL6, and IL8 concentrations in the fractured limbs were elevated (P |
| Databáze: | OpenAIRE |
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