Respiratory Viral Infections in Adults With and Without Chronic Obstructive Pulmonary Disease
| Autor: | Robert L. Atmar, Stephen B. Greenberg, M. L. Allen, Joan Wilson |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Respiratory Tract Diseases Critical Care and Intensive Care Medicine Internal medicine Epidemiology medicine Humans Longitudinal Studies Lung Diseases Obstructive Aged COPD business.industry Respiratory disease Middle Aged medicine.disease respiratory tract diseases Surgery Hospitalization medicine.anatomical_structure Influenza Vaccines Virus Diseases Cohort Etiology Female Viral disease business Cohort study Respiratory tract |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 162:167-173 |
| ISSN: | 1535-4970 1073-449X |
| Popis: | A longitudinal cohort study of older adults with chronic obstructive pulmonary disease (COPD) who were stratified by FEV(1) at enrollment was done to define the etiology, frequency, severity, and medical-care impact of respiratory tract viral infections (RTVIs). Controls consisted of a group of subjects of comparable age with the patients. RTVIs were documented in 44% of observed acute respiratory illnesses in control subjects and in 27% of COPD subjects, who were followed for mean periods of 35 and 26 mo, respectively. In this heavily influenza-vaccinated cohort ( approximately 90% vaccinated each year), picornaviruses, parainfluenza viruses, and coronaviruses were most commonly identified. Mean time to return to clinical baseline was approximately 2 wk in each group. Control and COPD subjects with mild airways obstruction (baseline FEV(1) >/= 50% predicted) had few emergency-center visits or hospitalizations. Approximately half of COPD subjects with moderate/severe COPD (baseline FEV(1) < 50% predicted) had at least one emergency-center visit and/or hospitalization for acute respiratory illness. RTVIs were documented in 23% of hospitalizations and in 45% of patients admitted between December and March. RTVIs have a major impact on utilization of health care resources for COPD patients with moderate/severe airways obstruction. |
| Databáze: | OpenAIRE |
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