6-Hydroxydopamine-induced aggression in cats: effects of various drugs
| Autor: | S.K. Krstić, Beleslin Db, Samardzić R |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Phenoxybenzamine Clinical Biochemistry Sodium Chloride Pharmacology Toxicology Biochemistry Hydroxydopamines Behavioral Neuroscience chemistry.chemical_compound Dopamine Internal medicine Mecamylamine medicine Antazoline Animals Oxidopamine Practolol Biological Psychiatry Injections Intraventricular Ganglionic blocking agent Hydroxydopamine Parasympatholytics Aggression Endocrinology chemistry Cats Histamine H1 Antagonists Sympatholytics Female Hexamethonium Serotonin Antagonists medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 24:1821-1823 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(86)90530-7 |
| Popis: | The effects of intracerebroventricular injections (ICV) in the unanesthetized cat of antimuscarinic drugs, ganglionic blocking agents, alpha and beta adrenergic blocking substances, dopamine and 5-hydroxytryptamine (5-HT) antagonists, and an antihistamine on aggressive behavior produced by 6-hydroxydopamine injected similarly was investigated. It was found that atropine, hyoscine, hexamethonium, mecamylamine, yohimbine, phenoxybenzamine, propranolol, practolol, chlorpromazine, haloperidol, antazoline and methysergide exerted virtually no effect on the pattern of aggressive responses evoked by ICV 6-hydroxydopamine. It is thus concluded that the aggressive behavior induced by 6-hydroxydopamine isnot related to the release of acetylcholine, norepinephrine, dopamine, histamine or 5-hydroxytryptamine from endogenous storage sites in the brain. |
| Databáze: | OpenAIRE |
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