Association of free fatty acids (FFA) and tumor necrosis factor-alpha (TNF-alpha) and insulin-resistant metabolic disorder
| Autor: | M. Tokunaga, S. Minagawa, Eiji Ohmura, T. Sato, D. Hosaka, A. Matsuda, M. Yazawa, S. Kawazu, A. Tsuchida, Y. Imai, Hitoshi Ishida |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Biology Fatty Acids Nonesterified Biochemistry Group A Group B Body Mass Index Endocrinology Insulin resistance Internal medicine medicine Humans Metabolic Syndrome Adiponectin Tumor Necrosis Factor-alpha Biochemistry (medical) Metabolic disorder nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Blood pressure Insulin Resistance Body mass index Homeostasis |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 39(3) |
| ISSN: | 0018-5043 |
| Popis: | The roles of free fatty acids (FFA), tumor necrosis factor-alpha (TNF-alpha), and adiponectin in the development of the insulin-resistant metabolic disorder in several subjects have been studied. A total of 70 Japanese male subjects were selected according to the following three sets of criteria: subjects in group A had, (1) a fasting plasma glucose (FPG)or=110 to140 mg/dl, (2) a triglyceride (TG) levelor=150 mg/dl, (3) a systolic blood pressure (SBP)or=140 and/or diastolic blood pressure (DBP)or=90 mmHg, and (4) a body mass index (BMI)or=25 kg/m2 (age=53.4+/-8.5 years, BMI=27.0+/-1.3 kg/m2, n=16). Subjects in group B had, (1) FPG110 mg/dl, (2) TG150 mg/dl, (3) SBP140 and DBP90 mmHg, and (4) BMIor=25 kg/m2 (age=47.2+/-10.3 years, BMI=26.6+/-1.31 kg/m2, n=38). Subjects in group C had, (1) FPG110 mg/dl, (2) TG150 mg/dl, (3) SBP140 and DBP90 mmHg, and (4) 20or=BMI22 kg/m2 (age=50.4+/-9.3 years, BMI=20.9+/-0.6 kg/m2, n=16). The homeostasis model assessment of insulin resistance in group A (2.7+/-1.4) was significantly higher (p0.0001) than in groups B (1.6+/-0.7) and C (0.9+/-0.5). FFA in group A (1.17+/-0.57 mEq/l) was significantly higher than in groups B (0.62+/-0.23 mEq/l) and C (0.48+/-0.16 mEq/l) (p0.0001). Serum TNF-alpha in group A (1.36+/-0.62 pg/ml) was significantly higher than in groups B (0.95+/-0.35 pg/ml; p=0.003) and C (0.76+/-0.09 pg/ml; p=0.0013). No significant differences in the serum level of adiponectin were observed between groups A and B or between groups B and C. The results suggest that FFA and possibly TNF-alpha levels are closely related to the development of insulin resistance in subjects with metabolic disorders. |
| Databáze: | OpenAIRE |
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