Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013
Autor: | Veasna Duong, Ruben O. Donis, Amanda Balish, Reiko Tsuyuoka, Michael Prouty, Paul F. Horwood, San Sorn, Borann Sar, Nancy J. Cox, Dora Warren, Phillipe Buchy, Ikwo Oboho, Arnaud Tarantola, Touch Sok, Julie Villanueva, William G. Davis, A. Danielle Iuliano, C. Todd Davis, Paul Kitsutani, Marc-Alain Widdowson, Sharmi Thor, Lotfi Allal, Savuth Chin, Amy Parry, Stephen Lindstrom, Denis R. St. Laurent, Davun Holl, Heng Seng Seng, Yunho Jang, Srey Viseth Horm, Beat Richner, Sareth Rith, Nora Chea, Sovann Ly |
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Přispěvatelé: | Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Centers for Disease Control and Prevention [Phnom Penh], Embassy of the United States of America, National Institute of Public Health [Cambodge], Ministry of Health [Phnom Penh], Kantha Bopha Hospitals Foundation, National Veterinary Research Institute [Phnom Penh], World Health Organization [Phnom Penh] (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Food and Agriculture Organization, This work was funded by the World Health Organization (WHO) in Cambodia, the Food and Agriculture Organization (FAO) in Cambodia, and the Office of the Assistant Secretary for Preparedness and Response within the U.S. Department of Health and Human Services. We thank the Centers for Disease Control and Prevention’s Division of Global Disease Detection and Emergency Response for their support. |
Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Male
MESH: Sequence Analysis DNA Hemagglutinin Glycoproteins Influenza Virus MESH: Genetic Markers medicine.disease_cause MESH: Genotype [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Child Genotype Cluster Analysis Respiratory system MESH: Phylogeny Child Phylogeny 0303 health sciences MESH: Middle Aged MESH: Influenza Human MESH: Hemagglutinin Glycoproteins Influenza Virus virus diseases Middle Aged MESH: Infant MESH: Amino Acid Substitution 3. Good health Child Preschool Female Cambodia Receptor binding specificity Adult Genetic Markers MESH: Influenza A Virus H5N1 Subtype Adolescent MESH: Virus Attachment Immunology Molecular Sequence Data Mutation Missense Virus Attachment Viral quasispecies Biology Microbiology Virus 03 medical and health sciences Phylogenetics Virology Influenza Human medicine Humans 030304 developmental biology MESH: Adolescent MESH: Mutation Missense MESH: Humans MESH: Molecular Sequence Data Influenza A Virus H5N1 Subtype 030306 microbiology MESH: Cambodia MESH: Child Preschool Infant MESH: Adult Sequence Analysis DNA MESH: Cluster Analysis Influenza A virus subtype H5N1 MESH: Male Genetic Diversity and Evolution Amino Acid Substitution Genetic marker Insect Science MESH: Female |
Zdroj: | Journal of Virology Journal of Virology, American Society for Microbiology, 2014, 88 (23), pp.13897-13909. ⟨10.1128/JVI.01887-14⟩ |
ISSN: | 0022-538X 1098-5514 |
Popis: | Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further. |
Databáze: | OpenAIRE |
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