Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013

Autor: Veasna Duong, Ruben O. Donis, Amanda Balish, Reiko Tsuyuoka, Michael Prouty, Paul F. Horwood, San Sorn, Borann Sar, Nancy J. Cox, Dora Warren, Phillipe Buchy, Ikwo Oboho, Arnaud Tarantola, Touch Sok, Julie Villanueva, William G. Davis, A. Danielle Iuliano, C. Todd Davis, Paul Kitsutani, Marc-Alain Widdowson, Sharmi Thor, Lotfi Allal, Savuth Chin, Amy Parry, Stephen Lindstrom, Denis R. St. Laurent, Davun Holl, Heng Seng Seng, Yunho Jang, Srey Viseth Horm, Beat Richner, Sareth Rith, Nora Chea, Sovann Ly
Přispěvatelé: Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Centers for Disease Control and Prevention [Phnom Penh], Embassy of the United States of America, National Institute of Public Health [Cambodge], Ministry of Health [Phnom Penh], Kantha Bopha Hospitals Foundation, National Veterinary Research Institute [Phnom Penh], World Health Organization [Phnom Penh] (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Food and Agriculture Organization, This work was funded by the World Health Organization (WHO) in Cambodia, the Food and Agriculture Organization (FAO) in Cambodia, and the Office of the Assistant Secretary for Preparedness and Response within the U.S. Department of Health and Human Services. We thank the Centers for Disease Control and Prevention’s Division of Global Disease Detection and Emergency Response for their support.
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
MESH: Sequence Analysis
DNA
Hemagglutinin Glycoproteins
Influenza Virus
MESH: Genetic Markers
medicine.disease_cause
MESH: Genotype
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
MESH: Child
Genotype
Cluster Analysis
Respiratory system
MESH: Phylogeny
Child
Phylogeny
0303 health sciences
MESH: Middle Aged
MESH: Influenza
Human
MESH: Hemagglutinin Glycoproteins
Influenza Virus
virus diseases
Middle Aged
MESH: Infant
MESH: Amino Acid Substitution
3. Good health
Child
Preschool
Female
Cambodia
Receptor binding specificity
Adult
Genetic Markers
MESH: Influenza A Virus
H5N1 Subtype
Adolescent
MESH: Virus Attachment
Immunology
Molecular Sequence Data
Mutation
Missense
Virus Attachment
Viral quasispecies
Biology
Microbiology
Virus
03 medical and health sciences
Phylogenetics
Virology
Influenza
Human
medicine
Humans
030304 developmental biology
MESH: Adolescent
MESH: Mutation
Missense
MESH: Humans
MESH: Molecular Sequence Data
Influenza A Virus
H5N1 Subtype
030306 microbiology
MESH: Cambodia
MESH: Child
Preschool
Infant
MESH: Adult
Sequence Analysis
DNA
MESH: Cluster Analysis
Influenza A virus subtype H5N1
MESH: Male
Genetic Diversity and Evolution
Amino Acid Substitution
Genetic marker
Insect Science
MESH: Female
Zdroj: Journal of Virology
Journal of Virology, American Society for Microbiology, 2014, 88 (23), pp.13897-13909. ⟨10.1128/JVI.01887-14⟩
ISSN: 0022-538X
1098-5514
Popis: Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.
Databáze: OpenAIRE
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