Isquemia de extremidades inferiores secundaria a arteritis de la arteria temporal
| Autor: | Leopoldo Mariné M, Pedro Sfeir V., Cristian Zárate B., Renato Mertens M, María Eugenia Martínez R-E., José I. Torrealba F., Obren Drazic B., Michel Bergoeing R, José F Vargas S., Francisco Valdés E |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2020 |
| Předmět: |
Aortic arch
medicine.medical_specialty Arteritis Exacerbation business.industry Arterial stenosis Giant Cell Arteritis General Medicine medicine.disease Systemic inflammation Giant Cells Intermittent claudication Surgery Femoral Artery Giant cell arteritis chemistry.chemical_compound Tocilizumab chemistry medicine.artery Occlusion medicine medicine.symptom business |
| Zdroj: | Revista médica de Chile v.148 n.10 2020 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | Giant cell arteritis is more common in women older than 60 years, is associated with systemic inflammation symptoms and mainly involves the aortic arch and cranial arteries, specially the temporal artery. Symptomatic lower extremity arterial stenosis or occlusion is uncommon and can lead to limb loss. We report a 73-year-old woman presenting with a one-month history of lower extremity intermittent claudication of sudden onset. She also complained of fever, malaise, headache and weight loss. A non-invasive vascular study showed moderate femoral popliteal occlusive disease, with and abnormal ankle-brachial index (0.68 and 0.83 on right and left sides, respectively). An angio-computed tomography showed thickening of the aortic wall and severe stenosis in both superficial femoral arteries. Steroidal treatment was started, and a temporal artery biopsy was performed confirming giant cell arteritis. Six weeks after steroid therapy the patient had a complete remission of symptoms. A serologic exacerbation was subsequently treated with a humanized monoclonal antibody against the interleukin-6 receptor Tocilizumab, obtaining long time remission. |
| Databáze: | OpenAIRE |
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