Chicory: Understanding the Effects and Effectors of This Functional Food

Autor: Céline L. Pouille, Souad Ouaza, Elise Roels, Josette Behra, Melissa Tourret, Roland Molinié, Jean-Xavier Fontaine, David Mathiron, David Gagneul, Bernard Taminiau, Georges Daube, Rozenn Ravallec, Caroline Rambaud, Jean-Louis Hilbert, Benoit Cudennec, Anca Lucau-Danila
Přispěvatelé: Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Biologie des Plantes et Innovation - UR UPJV 3900 (BIOPI), Université de Picardie Jules Verne (UPJV)-Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Université d'Artois (UA)-Université de Liège-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Plateforme Analytique (PFA), Université de Picardie Jules Verne (UPJV)
Rok vydání: 2022
Předmět:
Zdroj: Nutrients
Nutrients, 2022, 14 (5), pp.957. ⟨10.3390/nu14050957⟩
Nutrients; Volume 14; Issue 5; Pages: 957
ISSN: 2072-6643
DOI: 10.3390/nu14050957⟩
Popis: International audience; Industrial chicory has been the subject of numerous studies, most of which provide clinical observations on its health effects. Whether it is the roasted root, the flour obtained from the roots or the different classes of molecules that enter into the composition of this plant, understanding the molecular mechanisms of action on the human organism remains incomplete. In this study, we were interested in three molecules or classes of molecules present in chicory root: fructose, chlorogenic acids, and sesquiterpene lactones. We conducted experiments on the murine model and performed a nutrigenomic analysis, a metabolic hormone assay and a gut microbiota analysis, associated with in vitro observations for different responses. We have highlighted a large number of effects of all these classes of molecules that suggest a pro-apoptotic activity, an anti-inflammatory, antimicrobial, antioxidant, hypolipidemic and hypoglycemic effect and also an important role in appetite regulation. A significant prebiotic activity was also identified. Fructose seems to be the most involved in these activities, contributing to approximately 83% of recorded responses, but the other classes of tested molecules have shown a specific role for these different effects, with an estimated contribution of 23–24%.
Databáze: OpenAIRE
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