Does Abnormal QT Interval Prolongation Reflect Autonomic Dysfunction in Diabetic Patients? QTc Interval Measure Versus Standardized Tests in Diabetic Autonomic Neuropathy
| Autor: | M. Borra, M Veglio, P Cavallo Perin, A. Chinaglia |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Posture Sensitivity and Specificity QT interval Cohort Studies Diagnosis Differential Endocrinology Diabetic Neuropathies Heart Rate Predictive Value of Tests Diabetes mellitus Internal medicine Heart rate Internal Medicine medicine Humans Diabetic Autonomic Neuropathy Analysis of Variance medicine.diagnostic_test business.industry Respiration Middle Aged medicine.disease Long QT Syndrome Diabetes Mellitus Type 1 Blood pressure Cough Diabetes Mellitus Type 2 Predictive value of tests Cardiology Regression Analysis Female Analysis of variance business Electrocardiography |
| Zdroj: | Diabetic Medicine. 12:302-306 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.1995.tb00481.x |
| Popis: | The question as to whether the QTc interval correlates with five cardiovascular tests (deep breathing test, 30/15 ratio test, lying to standing test, cough test, and postural blood pressure test) for the diagnosis of diabetic autonomic neuropathy (DAN) was investigated in 168 (38 Type 1, 130 Type 2) consecutive outpatients (mean age 54.9 +/- 11.2 years). QT interval was measured on an ECG recorded at rest and QTc calculated according to Bazett's formula. The percentage of patients with a QTc greater than 0.440 s was: absent DAN = 11% (n = 7), probable DAN = 7% (n = 4), definite DAN = 23% (n = 12) (p < 0.05), and the mean (+/- SD) QTc values were 0.403 +/- 0.028 s, 0.405 +/- 0.023 s, and 0.421 +/- 0.026 s, respectively. A significant correlation between QTc duration and DAN score of autonomic cardiovascular test results (r = 0.34, p < 0.0001) was observed. The calculated specificity, sensitivity, positive and negative predictive values were 89%, 15%, 70% and 37%, respectively. In conclusion, QTc can be considered as an additional specific test in the assessment of diabetic autonomic neuropathy, but cannot replace the standard battery of cardiovascular tests. |
| Databáze: | OpenAIRE |
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