The effects of escitalopram on working memory and brain activity in healthy adults during performance of the n-back task
| Autor: | Klaus P. Ebmeier, Enrico Simonotto, Edgar P. Spencer, Emma J. Rose |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Inferior frontal gyrus Citalopram Audiology Brain mapping Drug Administration Schedule Cognition Memory Functional neuroimaging medicine Humans Escitalopram Effects of sleep deprivation on cognitive performance Psychiatry Pharmacology n-back Brain Mapping Cross-Over Studies Working memory Brain Magnetic Resonance Imaging Antidepressive Agents Functional imaging Female Psychology medicine.drug |
| Zdroj: | Psychopharmacology. 185:339-347 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-006-0334-2 |
| Popis: | RATIONALE: Psychotropic medication affects cognition and brain function, making it a potential confounder in functional neuroimaging studies of psychiatric patients. OBJECTIVE: To determine whether the sub-acute administration of an antidepressant (escitalopram) would induce differences in cognitive performance and associated brain function, which could be observed within the normal power of a functional imaging study. MATERIALS AND METHODS: Healthy adults (N=10) received a short course of escitalopram (10 mg/day for 7 days). Participants performed a parametric working memory (WM) task during BOLD fMRI, both while medication-free and after medication. To control for order effects, the medication-free examination was completed by half the subjects before starting medication and by the other half at least one week after medication. RESULTS: Escitalopram had no significant effect on WM accuracy or reaction time. Preliminary analysis of the imaging data revealed no significant (p(corrected) |
| Databáze: | OpenAIRE |
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