Cutaneous manifestations and management of hematologic neoplasms
| Autor: | John P. Greer, Jonathan J. Douds, Olalekan O. Oluwole, Mary Ann Thompson, John A. Zic |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Myeloid Lymphoma B-Cell Skin Neoplasms Paraneoplastic Syndromes Cutaneous B-cell lymphoma Hematologic Neoplasms Multimodality Therapy Lymphoma T-Cell 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Mycosis Fungoides hemic and lymphatic diseases medicine Humans Anaplastic large-cell lymphoma Mycosis fungoides business.industry Cutaneous T-cell lymphoma Hematology medicine.disease Lymphoma medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis business |
| Zdroj: | Seminars in oncology. 43(3) |
| ISSN: | 1532-8708 |
| Popis: | Many malignant hematologic neoplasms can directly and indirectly involve the skin with lesions that are disfiguring, painful, and compromise integumentary function. The majority of lymphomas that directly infiltrate the skin are of T-cell origin but B-cell lymphomas, and other hematologic neoplasms, including acute myeloid and lymphoblastic leukemias, can also have cutaneous involvement, whereas some have an indolent course, eg, mycosis fungoides and marginal zone lymphoma, and easily respond to localized therapy with overall survival (OS) measured in years to decades. Others have a more clinically aggressive course, eg, natural killer (NK)/T-cell lymphoma and diffuse large B-cell lymphoma, leg type, that require high-dose multimodality therapy, and have an OS measured in months to a few years. Lymphoma can also lead to secondary cutaneous alterations, including a variety of paraneoplastic phenomena. We present an overview of direct and indirect skin involvement by malignant lymphocytes and other hematologic neoplasms. We also describe molecular and immunophenotypic aspects of these diseases and how they are treated. |
| Databáze: | OpenAIRE |
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