The value of multi ultra high-b-value DWI in grading cerebral astrocytomas and its association with aquaporin-4
| Autor: | Le Wang, Xiao-chun Wang, Yan Tan, Hui Zhang, Jiang-bo Qin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Astrocytoma Aquaporins Spearman's rank correlation coefficient 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging RNA Messenger Grading (tumors) Aged Retrospective Studies Aquaporin 4 Receiver operating characteristic Aquaporin 1 Full Paper Chemistry Brain Neoplasms Area under the curve General Medicine Middle Aged High B-Value body regions Diffusion Magnetic Resonance Imaging ROC Curve 030220 oncology & carcinogenesis Cerebral Astrocytomas Female Neoplasm Grading 030217 neurology & neurosurgery |
| Zdroj: | The British journal of radiology. 91(1086) |
| ISSN: | 1748-880X |
| Popis: | OBJECTIVE: To investigate the value of multi-ultrahigh-b-value diffusion-weighted imaging (UHBV-DWI) in differentiating high-grade astrocytomas (HGAs) from low-grade astrocytomas (LGAs), analyze its association with aquaporin (AQP) expression. METHODS: 40 astrocytomas divided into LGAs (N = 15) and HGAs (N = 25) were studied. Apparent diffusion coefficient (ADC) and UHBV-ADC values in solid parts and peritumoral edema were compared between LGAs and HGAs groups by the t-test. Using receiver operating characteristic curves to identify the better parameter. Using real time polymerase chain reaction to assess AQP messenger ribonucleic acid (mRNA). Using spearman correlation analysis to assess the correlation of AQP mRNA with each parameter. RESULTS: ADC values in solid parts of HGAs were significantly lower than LGAs (p = 0.02), while UHBV-ADC values of HGAs were significantly higher than LGAs (p 0.05); ADC value showed a negative correlation with AQP4 mRNA (r = −0.357; p = 0.024). UHBV-ADC value positively correlated with the AQP4 mRNA (r = 0.646; p |
| Databáze: | OpenAIRE |
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