Acute Remodeling of Parenchyma in Pulmonary and Extrapulmonary ARDS. An Autopsy Study of Collagen-Elastic System Fibers
| Autor: | Paulo Hilário Nascimento Saldiva, Gregório Santiago Montes, C Hoelz, Carmen Silvia Valente Barbas, Vera Luiza Capelozzi, Elnara Marcia Negri |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Pathology medicine.medical_specialty ARDS Adolescent medicine.medical_treatment Autopsy Lung injury Pathology and Forensic Medicine Parenchyma Image Processing Computer-Assisted Humans Medicine Aged Retrospective Studies Mechanical ventilation Respiratory Distress Syndrome Wound Healing Lung business.industry Alveolar septum Cell Biology Middle Aged Elastic Tissue medicine.disease Extracellular Matrix Pulmonary Alveoli medicine.anatomical_structure Heart failure Acute Disease Collagen business |
| Zdroj: | Pathology - Research and Practice. 198:355-361 |
| ISSN: | 0344-0338 |
| DOI: | 10.1078/0344-0338-00266 |
| Popis: | This study aimed at evaluating acute pulmonary remodeling, focusing on alterations of fibers of the collagenous and elastic systems in ARDS in the exudative phase according to the etiology of the disease. ARDS patients (n = 23), who died in our institution between 1989 and 1997, were retrospectively studied. Ten patients who died in accidents, without any pathological changes in the lung, and ten patients with Congestive Heart Failure (CHF), submitted to mechanical ventilation, were used as control groups. Histological slides were sampled from the autopsied lungs and stained by the Picrosirius and Weigert's resorcin-fuchsin methods. The fiber content of the collagenous and elastic systems of the alveolar septum was measured by image analysis. All patients were in the early ARDS phase (n = 23), 10 pulmonary and 13 extra-pulmonary diseases. Collagen content was greater in pulmonary (1.23+/-0.27) than in extra-pulmonary (0.92+/-0.39) ARDS in the early phase of the disease (p = 0.05). No differences were observed concerning the elastic fibers' content. Extracellular matrix (ECM) remodeling occurs early in the development of acute lung injury and appears to depend on the site of initial insult (pulmonary or extrapulmonary). The present study provides the basis for a prospective, controlled investigation. |
| Databáze: | OpenAIRE |
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