Lipoprotein lipase as a humoral agent of the physiological anticoagulant system
| Autor: | B.A. Kudrjashov, G.G. Bazasian |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
Very low-density lipoprotein
medicine.medical_specialty Lipoprotein lipase biology Cholesterol medicine.drug_class Anticoagulant Triacylglycerol lipase Anticoagulants Thrombosis General Medicine Heparin Lipoprotein Lipase chemistry.chemical_compound Thrombin Endocrinology chemistry Internal medicine medicine biology.protein Humans Lipase Blood Coagulation medicine.drug |
| Zdroj: | Journal of Atherosclerosis Research. 3:199-205 |
| ISSN: | 0368-1319 |
| DOI: | 10.1016/s0368-1319(63)80070-8 |
| Popis: | Summary In experiments with 450 white male rats it was established that application of a fatty diet (after W ILGRAM ) for 8 months resulted in a persistent lipemia. In such animals the activity of the plasma lipoprotein lipase was reduced to half of that of control rats kept on an ordinary laboratory diet. Intravenous heparin injection produced a considerable activation of lipoprotein lipase in test animals without reaching, however, the same level as that observed in the controls after injections of similar heparin doses. An intravenous thrombin injection into normal animals caused an activation of lipoprotein lipase due to the appearance in the blood of an excessive amount of heparin secreted by the physiological anticoagulant system in response to thrombin injected. Thus, the development of a pre-thrombotic state in animals kept on a fatty diet, is accompanied by a decrease in the activity of lipoprotein lipase. This may be due to a lack of heparin and possibly also of the enzyme itself. From these statements it is inferred that lipoprotein lipase is related to the function of the physiological anticoagulant system. |
| Databáze: | OpenAIRE |
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