Interfacing Graphene-Based Materials With Neural Cells
| Autor: | Mattia Bramini, Giulio Alberini, Elisabetta Colombo, Martina Chiacchiaretta, Mattia L. DiFrancesco, José F. Maya-Vetencourt, Luca Maragliano, Fabio Benfenati, Fabrizia Cesca |
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| Přispěvatelé: | Bramini, M, Alberini, G, Colombo, E, Chiacchiaretta, M, Difrancesco, Ml, Maya-Vetencourt, Jf, Maragliano, L, Benfenati, F, Cesca, F |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
computational modeling
Materials science Graphene derivatives Cognitive Neuroscience brain Neuroscience (miscellaneous) FOS: Physical sciences Nanotechnology Review 02 engineering and technology Substrate (printing) scaffold 010402 general chemistry 01 natural sciences law.invention lcsh:RC321-571 Cellular and Molecular Neuroscience Developmental Neuroscience law graphene neurology blood-brain barrier nanomedicine scaffolds smart materials Neural Growth Physics - Biological Physics Nanoscopic scale lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Organic electronics Graphene smart material 021001 nanoscience & nanotechnology 3. Good health 0104 chemical sciences Biological Physics (physics.bio-ph) Interfacing Quantitative Biology - Neurons and Cognition FOS: Biological sciences Drug delivery Blood-brain barrier Brain Computational modeling Nanomedicine Neurology Scaffolds Smart materials Neurons and Cognition (q-bio.NC) 0210 nano-technology Neuroscience |
| Zdroj: | Frontiers in Systems Neuroscience, Vol 12 (2018) Frontiers in Systems Neuroscience |
| ISSN: | 1662-5137 |
| Popis: | The scientific community has witnessed an exponential increase in the applications of graphene and graphene-based materials in a wide range of fields. For what concerns neuroscience, the interest raised by these materials is two-fold. On one side, nanosheets made of graphene or graphene derivatives (graphene oxide, or its reduced form) can be used as carriers for drug delivery. Here, an important aspect is to evaluate their toxicity, which strongly depends on flake composition, chemical functionalization and dimensions. On the other side, graphene can be exploited as a substrate for tissue engineering. In this case, conductivity is probably the most relevant amongst the various properties of the different graphene materials, as it may allow to instruct and interrogate neural networks, as well as to drive neural growth and differentiation. In this review, we try to give a comprehensive view of the accomplishments and new challenges of the field, as well as which in our view are the most exciting directions to take in the immediate future. These include the need to engineer multifunctional nanoparticles able to cross the blood-brain-barrier to reach neural cells, and to achieve on-demand delivery of specific drugs. We describe the state-of-the-art in the use of graphene materials to engineer three-dimensional scaffolds to drive neuronal growth and regeneration in vivo, and the possibility of using graphene as a component of hybrid composites/multi-layer organic electronics devices. Last but not least, we address the need of an accurate theoretical modeling of the interface between graphene and biological material, by modeling the interaction of graphene with proteins and cell membranes at the nanoscale, and describing the physical mechanism(s) of charge transfer by which the various graphene materials can influence the excitability and physiology of neural cells. Comment: Invited Review paper, 42 pages, 6 figures. This document is the unedited Author's version of a Submitted Work that was subsequently accepted for publication in Frontiers in Systems Neuroscience. To access the final edited and published work see https://www.frontiersin.org/articles/10.3389/fnsys.2018.00012/full |
| Databáze: | OpenAIRE |
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