The Role of Dura Mater and Free Peritoneal Graft in the Reinforcement of Colon Anastomosis

Autor:	Mustafa Sahin, Ramazan Eryilmaz, Munir Samuk, Adem Akçakaya, Osman Baran Tortum, Suha Goksel
Rok vydání:	2007
Předmět:	Male medicine.medical_specialty Lower bowel Colon Dura mater Tissue Adhesions Anastomosis Dehiscence Random Allocation Postoperative Complications Tensile Strength Materials Testing Surgical Wound Dehiscence Pressure medicine Animals Humans Surgical Wound Infection Rats Wistar Bioprosthesis Wound Healing business.industry Primary anastomosis Abdominal Wall Anastomosis Surgical Colorectal surgery Rats Surgery medicine.anatomical_structure Anesthesia Dura Mater Peritoneum business Complication Omentum Colon anastomosis
Zdroj:	Journal of Investigative Surgery. 20:15-21
ISSN:	1521-0553 0894-1939
Popis:	Anastomotic leakage is the most important complication leading to morbidity and mortality in colorectal surgery. To prevent anastomotic leakage, a number of drugs with different mechanisms of action were tested, and autogenic grafts and various synthetic materials were used for reinforcement of the anastomotic region. In this experimental study aimed at preventing anastomotic leakage and dehiscence, we used dehydrated, lyophilized human dura mater and free peritoneal graft for reinforcement of anastomotic region after primary repair in rats, and investigated whether they are superior to primary anastomosis. The rats were sacrificed 3 and 7 days postoperatively. The anastomotic region was observed macroscopically for adhesions, bursting pressure of bowel was measured for tensile strength of the anastomosis, and histopathologic evaluation was performed for anastomotic healing. Compared to the control group, dura mater and free peritoneal graft groups displayed a lower bowel bursting pressure (p.05), worse anastomotic healing (p.05), a higher number of adhesions, and presence of anastomotic stricture. In conclusion, both human dura mater and free peritoneal graft reinforcement groups had worse anastomosis healing. The results could be attributed to avascularity of grafts and to aggravated adhesions between anastomosis and intra-abdominal organs, which created a favorable environment for reproduction and dispersion of bacteria and consequently led to decreased anastomosis healing.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c775e0e9ded73e0da97615edd24f6c88 https://doi.org/10.1080/08941930601126108 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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