Identifying the risk of obstructive sleep apnea in metabolic syndrome patients: Diagnostic accuracy of the Berlin Questionnaire

Autor: S. C. P. Rodrigues, Fernanda C. Ferreira-Camargo, Maria Fernanda Hussid, Akothirene C. B. Dutra-Marques, Maria Janieire N. N. Alves, Maria Urbana P. B. Rondon, Ivani C. Trombetta, Felipe X. Cepeda, Edgar Toschi-Dias, Leslie Virmondes
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Questionnaires
Male
Pulmonology
Apnea
Epidemiology
Blood Pressure
Polysomnography
Vascular Medicine
0302 clinical medicine
Risk Factors
Positive predicative value
Surveys and Questionnaires
Medicine and Health Sciences
Prevalence
Mass Screening
Metabolic Syndrome
Clinical Neurophysiology
education.field_of_study
Sleep Apnea
Obstructive
Multidisciplinary
medicine.diagnostic_test
Sleep apnea
Middle Aged
Neurology
Research Design
Cardiovascular Diseases
Predictive value of tests
Hypertension
Medicine
Female
Research Article
Adult
medicine.medical_specialty
Sleep Apnea
Science
Population
Research and Analysis Methods
Sensitivity and Specificity
03 medical and health sciences
stomatognathic system
Diagnostic Medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
Risk factor
education
Mass screening
Aged
Survey Research
business.industry
Reproducibility of Results
medicine.disease
nervous system diseases
respiratory tract diseases
Obstructive sleep apnea
Cross-Sectional Studies
030228 respiratory system
QUESTIONÁRIOS
Medical Risk Factors
Metabolic Disorders
Clinical Medicine
business
Sleep Disorders
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0217058 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1932-6203
Popis: Background Obstructive sleep apnea (OSA) is a risk factor frequently present in patients with metabolic syndrome (MetS). Additionally, moderate and severe OSA are highly prevalent in patients with cardiac disease, as they increase the riskfor cardiovascular events by 80%. The gold standard diagnostic method for OSA is overnight polysomnography (PSG), which remains unaffordable for the overall population. The aim of the present study was to evaluate whether the Berlin Questionnaire (BQ) is anuseful tool for assessing the risk of OSA in patients with MetS. Methods 97 patients, previously untreated and recently diagnosed with MetS (National Cholesterol Education Program, Adult Treatment Panel III, ATP-III) underwent a PSG. OSA was characterized by the apnea-hypopnea index (AHI). BQ was administered before PSG and we evaluated sensitivity, specificity, positive and negative predictive values, and accuracy. Results Of the 97 patients with MetS, 81 patients had OSA, with 47 (48.5%) presenting moderate and severe OSA. For all MetS with OSA (AHI≥5 events/hour), the BQ showed good sensitivity (0.65, 95% CI 0.54 to 0.76) and fair specificity (0.38, 95% CI 0.15–0.65) with a positive predictive value of 0.84, a negative predictive value of 0.18 and an 84% accuracy. Similarly, for moderate-to-severe OSA (AHI≥15 events/hour) we found good sensitivity (0.73, 95% CI 0.58–0.85) and fair specificity (0.40, 95% CI 0.27–0.55). Interestingly, for severe OSA (AHI≥30 events/hour), there was a very good sensitivity (0.91, 95% CI 0.72–0.99) and moderate specificity (0.42, 95% CI 0.31–0.54). Conclusion The BQ is a valid tool for screening the risk of OSA in MetS patients in general, and it is particularly useful in predicting severe OSA.
Databáze: OpenAIRE
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