Toxicokinetic mixture interactions between chlorinated aromatic hydrocarbons in the liver of the C57BL/6J mouse: 2. Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs)
| Autor: | Joost de Jongh, Martin van den Berg, Ruud Nieboer, Willem Seinen, Ingrid Schröders |
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| Rok vydání: | 1993 |
| Předmět: |
Polychlorinated Dibenzodioxins
Polymers Health Toxicology and Mutagenesis Pharmacology toxicology Toxicology chemistry.chemical_compound Mice Cytochrome P-450 Enzyme System Oral administration Cytochrome P-450 CYP1A1 Hydrocarbons Chlorinated Toxicokinetics Organic chemistry Animals Drug Interactions Benzofurans Chemistry General Medicine Halocarbon Polychlorinated Biphenyls Mice Inbred C57BL Interactive effects Liver Polychlorinated Dibenzo-p-dioxins Environmental chemistry C57bl 6j mouse Hepatic Elimination Chemical and Drug Induced Liver Injury Oxidoreductases |
| Zdroj: | Archives of toxicology. 67(9) |
| ISSN: | 0340-5761 |
| Popis: | Six groups of C57BL/6J mice received single oral doses of 1.5-10.6 nmol/kg 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PnCDD), 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin (HxCDD) or 2,3,4,7,8-pentachlorodibenzofuran (PnCDF) as single compounds or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). Two other groups of mice received a mixture of the first three compounds, either with or without HxCB. The hepatic deposition and elimination of the compounds and their CYP1a dependent 7-ethoxyresorufin-O-deethylation (EROD) activity were studied until day 175. Interactive effects on the hepatic deposition of PnCDD were observed in most of the mixed dose groups. For HxCDD and PnCDF interactive effects were either very small or absent. No interactive effects were observed on hepatic elimination rates of PnCDD, HxCDD or PnCDF. No evidence was found for the influence of HxCB cotreatment on the hepatic concentration-response curves of the three compounds or their mixture. Based on the results from the present study it is concluded that PCDDs, PCDFs and PCBs may influence each other's, toxicokinetics when administered in mixtures. |
| Databáze: | OpenAIRE |
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