Association study of CREBRF missense variant (rs373863828:G A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations
| Autor: | Ryutaro Ohtsuka, Yasuhiro Matsumura, Kazumi Natsuhara, Taro Yamauchi, Jun Ohashi, Minato Nakazawa, Tsukasa Inaoka, Takuro Furusawa, Izumi Naka, Ryosuke Kimura, Takafumi Ishida |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Aging medicine.medical_specialty Physiology Epidemiology Mutation Missense Biology 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Genetics medicine Missense mutation Humans Triglycerides Aged medicine.diagnostic_test Tumor Suppressor Proteins Cholesterol HDL Tonga Public Health Environmental and Occupational Health CREBRF gene Cholesterol LDL Middle Aged 030104 developmental biology Endocrinology Female Melanesia Lipid profile Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Annals of human biology. 45(3) |
| ISSN: | 1464-5033 |
| Popis: | A missense variant (rs373863828:G A; p.Arg457Gln) of the CREBRF gene is strongly associated with a higher body mass index (BMI; kg/mThe aim of this study is to examine the association of rs373863828:G A with levels of serum lipids in four Pacific populations.A total of 613 adult subjects were recruited from Tonga (Polynesians) and the Solomon Islands (Melanesians and Micronesians). Multiple regression analyses adjusted for age and sex were performed to examine the association of rs373863828 with levels of serum lipids in each population.A significant association of rs373863828:G A with lower level of HDL-cholesterol was detected in the Tonga population (β = -3.32 and p-value = 0.030). The expected change in HDL-cholesterol with respect to a single copy of the rs373863828-A allele was 3.32 mg/dL. However, the association between rs373863828-A and lower levels of HDL-cholesterol was not significant after further adjustment for BMI in the Tonga population (β = -2.32 and p-value = 0.13).The rs373863828-A allele may not directly affect the level of serum HDL-cholesterol independent of BMI. To confirm the present findings, association studies with large sample sizes and functional analyses are required. |
| Databáze: | OpenAIRE |
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