Clinical and Bacteriological Efficacy of Rifampin-Streptomycin Combination for Two Weeks followed by Rifampin and Clarithromycin for Six Weeks for Treatment of Mycobacterium ulcerans Disease
| Autor: | Justice Abotsi, Kingsley Asiedu, William Thompson, Mark Forson, Mohammed K. Abass, Richard Phillips, Tuah Wilson, Mark Wansbrough-Jones, Fred S. Sarfo, Yaw Ampem Amoako |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Buruli ulcer
medicine.medical_specialty medicine.drug_class Antibiotics Disease Gastroenterology Internal medicine Clarithromycin medicine polycyclic compounds Pharmacology (medical) Pharmacology biology business.industry biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Surgery Infectious Diseases Streptomycin Susceptibility Mycobacterium ulcerans Positive culture Erratum business After treatment medicine.drug |
| Popis: | Buruli ulcer, an ulcerating skin disease caused by Mycobacterium ulcerans infection, is common in tropical areas of western Africa. We determined the clinical and microbiological responses to administration of rifampin and streptomycin for 2 weeks followed by administration of rifampin and clarithromycin for 6 weeks in 43 patients with small laboratory-confirmed Buruli lesions and monitored for recurrence-free healing. Bacterial load in tissue samples before and after treatment for 6 and 12 weeks was monitored by semiquantitative culture. The success rate was 93%, and there was no recurrence after a 12-month follow-up. Eight percent had a positive culture 4 weeks after antibiotic treatment, but their lesions went on to heal. The findings indicate that rifampin and clarithromycin can replace rifampin and streptomycin for the continuation phase after rifampin and streptomycin administration for 2 weeks without any apparent loss of efficacy. |
| Databáze: | OpenAIRE |
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