Creatinine reduction ratio on post-transplant day two as criterion in defining delayed graft function
| Autor: | Angel L.M. de Francisco, R Escallada, Manuel Arias, Gema Fernández-Fresnedo, J.A Zubimendi, Julio G. Cotorruelo, Juan Carlos Ruiz, Celestino Piñera, R. Palomar, Emilio Rodrigo |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Statistics as Topic Urology Renal function Creatinine reduction ratio Ischemia Risk Factors Immunology and Allergy Medicine Humans Pharmacology (medical) Dialysis Kidney transplantation Transplantation business.industry Graft Survival Age Factors Middle Aged medicine.disease Kidney Transplantation Delayed Graft Function Tissue Donors Surgery Treatment Outcome Creatinine Multivariate Analysis Graft survival Female business Complication Immunosuppressive Agents |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 4(7) |
| ISSN: | 1600-6135 |
| Popis: | Delayed graft function (DGF) is a common complication after renal transplant, affecting its outcome. A common definition of DGF is the need for dialysis within the first week of transplantation, but this criterion has its drawbacks. We tried to validate an earlier and better defined parameter of DGF based on the creatinine reduction ratio on post-transplant day 2 (CRR2). We analyzed the clinical charts of 291 cadaver kidney recipients to compare the outcome of patients with immediate graft function (IGF), dialyzed patients (D-DGF) and nondialyzed CRR2-defined DGF patients (ND-DGF) and to identify risk factors for D-DGF and ND-DGF. Creatinine reduction ratio on post-transplant day 2 correlates significantly with renal function during the first year. Patients with IGF have significantly better renal function throughout the first year and better graft survival than patients with D-DGF and ND-DGF, while we found no differences either in renal function from days 30–365 or in graft survival between D-DGF and ND-DGF patients. Defining DGF by CRR2 allows an objective and quantitative diagnosis after transplantation and can help to improve post-transplant management. Creatinine reduction ratio on post-transplant day 2 correlates with renal function throughout the first year. The worse survival in the ND-DGF group is an important finding and a major advantage of the CRR2 criterion. |
| Databáze: | OpenAIRE |
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