Textural markers of ultrasonographic nerve alterations in amyotrophic lateral sclerosis
| Autor: | Hans-Jochen Heinze, Stefanie Schreiber, Susanne Petri, Frank Schreiber, Cornelia Garz, Stefan Vielhaber |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Echoic memory Physiology Disease duration pathology [Ulnar Nerve] 030105 genetics & heredity 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine diagnostic imaging [Amyotrophic Lateral Sclerosis] Peripheral nerve Physiology (medical) medicine Humans Nerve ultrasound ddc:610 Amyotrophic lateral sclerosis 610.72 pathology [Amyotrophic Lateral Sclerosis] Ulnar Nerve Aged Ultrasonography nerve ultrasound texture analysis biomarker sonographic texture amyotrophic lateral sclerosis business.industry Ultrasound Biomarker Middle Aged medicine.disease Control subjects diagnostic imaging [Median Nerve] innervation [Forearm] Median Nerve Forearm Texture analysis diagnostic imaging [Ulnar Nerve] pathology [Median Nerve] Biomarker (medicine) Functional status Female Neurology (clinical) Sonographic texture business 030217 neurology & neurosurgery Wit and Humor as Topic |
| Zdroj: | Muscle & nerve, 62(5):601-610 Muscle & nerve 62(5), 601-610 (2020). doi:10.1002/mus.27043 |
| DOI: | 10.25673/85364 |
| Popis: | Ultrasound has revealed cross‐sectional nerve area (CSA) reduction in amyotrophic lateral sclerosis (ALS), but little is known about the sonographic nerve texture beyond CSA alterations. In a large cohort of 177 ALS patients and 57 control subjects, we investigated the covariance and disease‐specific signature of several sonographic texture features of the median and ulnar nerves and their relationship to the patients’ clinical characteristics. ALS patients showed atrophic nerves, a loss of the intranerve structures’ echoic contrast, elevated coarseness, and a trend toward lower cluster shading compared with controls. A reduction in intranerve echoic contrast was related to longer disease duration and poorer functional status in ALS. Sonographic texture markers point toward a significant reorganization of the deep nerve microstructure in ALS. Future studies will be needed to further substantiate the markers’ potential to assess peripheral nerve alterations in ALS. |
| Databáze: | OpenAIRE |
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