Clinical characteristics and prognostic analysis of recurrent hemangiopericytoma in the central nervous system: a review of 46 cases
| Autor: | Weichuan Wu, Ying Zhang, Runfa Tian, Shuyu Hao, Liheng Bian, Baiyun Liu, Huan Li, Zonggang Hou, Feifan Xu |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Neurology Adolescent medicine.medical_treatment Radiosurgery Young Adult medicine Humans External beam radiotherapy Young adult Child Survival rate Aged Neoplasm Staging Retrospective Studies Hemangiopericytoma business.industry Brain Neoplasms Retrospective cohort study Middle Aged medicine.disease Prognosis Combined Modality Therapy Surgery Radiation therapy Survival Rate Oncology Child Preschool Cohort Female Neurology (clinical) Neoplasm Recurrence Local Radiotherapy Conformal business Tomography X-Ray Computed Follow-Up Studies |
| Zdroj: | Journal of neuro-oncology. 115(1) |
| ISSN: | 1573-7373 |
| Popis: | Central nervous system hemangiopericytoma (HPC) is a malignant vascularized mesenchymal tumor with a high rate of recurrence. Because of its rarity, few clinical characteristics and prognostic analysis information regarding recurrent HPC exist for doctors to pursue optimal outcomes. Forty-six recurrent HPC cases treated at our hospital between 2004 and 2012 were compiled into a single database based on a retrospective review of patient records, which were used to summarize the clinical characteristics. The mean survival of the recurrent HPC patients in our cohort was 41.6 ± 4.4 months, with 1-, 2-, 3-, and 4-year survival rates of 80.4, 65.2, 59.2, and 53.8 %, respectively. Thirty patients (65.2 %) suffered their first tumor recurrence, with a mean survival of 36.9 ± 4.1 months. Sixteen patients (34.8 %) suffered a second or further tumor recurrence, with a mean survival of 39.7 ± 7.0 months. Eighteen patients (39.1 %) died of all causes during the follow-up period, with a mean survival of 14.2 ± 5.6 months. Univariate and multivariate regression analyses showed that factors associated with good prognosis included recurrence age over 35 years, an interval between the first and second recurrence of more than 1 year and a clear boundary of the recurrent tumor. Gross total resection with adjuvant external beam radiotherapy could independently delay tumor recurrence of the second or more times and prolong the postoperative survival; thus, this strategy should be pursued as the initial treatment. |
| Databáze: | OpenAIRE |
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