Gastric Emptying Impacts the Timing of Meal Glucose Peak in Subjects With Uncomplicated Type 1 Diabetes
| Autor: | Annalisa Creanza, Roberta Lupoli, Gabriele Riccardi, Alba Rocco, E. Griffo, Brunella Capaldo, Gerardo Nardone, Lutgarda Bozzetto, Giovanni Annuzzi |
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| Přispěvatelé: | Lupoli, Roberta, Creanza, Annalisa, Griffo, Ettore, Nardone, Gerardo, Rocco, Alba, Bozzetto, Lutgarda, Annuzzi, Giovanni, Riccardi, Gabriele, Capaldo, Brunella |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry 030209 endocrinology & metabolism Biochemistry 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Bolus (medicine) Glucagon-Like Peptide 1 Diabetes mellitus Internal medicine Surveys and Questionnaires medicine Surveys and Questionnaire Humans Insulin Meal Meals Cross-Sectional Studie Breath test Type 1 diabetes medicine.diagnostic_test Gastric emptying business.industry Biochemistry (medical) medicine.disease Postprandial Period Ghrelin Postprandial Cross-Sectional Studies Diabetes Mellitus Type 1 Gastric Emptying 030211 gastroenterology & hepatology Female business Human |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 103(6) |
| ISSN: | 1945-7197 |
| Popis: | Context Diabetes mellitus is associated with gastrointestinal (GI) motility dysfunction, ranging from delayed to accelerated gastric emptying (GE). Objective To evaluate GE in patients with type 1 diabetes mellitus (T1DM) without chronic complications and to investigate its relation with postprandial glucose and GI hormone responses. Design Cross-sectional study. Setting/Participants Forty-two patients with T1DM free of chronic complications referred to Federico II University and 31 healthy controls similar for age, sex, and body mass index. Interventions/Main Outcome Measures GE was assessed by using the 13C-octanoate breath test with a standardized solid meal. During the meal, plasma glucose, ghrelin, and glucagon-like peptide 1 (GLP-1) responses were assessed, and GI symptoms were evaluated by a specific questionnaire. Results Patients with T1DM showed a significantly slower GE half-emptying time (GE t1/2) (113 ± 34 minutes) than did controls (89 ± 17 minutes; P < 0.001). Thirty-six percent of T1DM showed a delayed GE (t1/2 > 120 minutes), whereas all controls showed a normal GE. When patients with T1DM were stratified according to GE t1/2, postmeal glucose response was significantly different between those with delayed and those with normal GE (P = 0.013). In particular, patients with T1DM and delayed GE showed a significantly longer mean time to peak glucose than did patients with normal GE (P = 0.004). In addition, GE t1/2 was an independent predictor of the time to peak glucose (β = 0.329; P = 0.025). GLP-1 and ghrelin responses to the test meal, as well as the prevalence of GI symptoms, were similar between patients with T1DM and controls and between patients with T1DM with normal GE and those with delayed GE. Conclusions Delayed GE time is associated with a longer time to peak glucose. GE evaluation could be useful for individualizing the timing of preprandial insulin bolus in patients with T1DM. |
| Databáze: | OpenAIRE |
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