Intensive postremission chemotherapy in Taiwanese adults with acute myelogenous leukemia
| Autor: | Hui-Chi Hsu, Jacqueline Ming Liu, Chao-Hung Ho, Jyh-Pyng Gau, Wing-Keung Chau |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Acute promyelocytic leukemia medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment Antimetabolite Disease-Free Survival Myelogenous Internal medicine Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor medicine Humans Pharmacology (medical) Chemotherapy business.industry Remission Induction Cytarabine Hematopoietic Stem Cell Transplantation Consolidation Chemotherapy General Medicine Middle Aged medicine.disease Surgery Survival Rate Transplantation Leukemia Myeloid Acute Leukemia Female Mitoxantrone Idarubicin business medicine.drug |
| Zdroj: | Advances in Therapy. 18:67-74 |
| ISSN: | 1865-8652 0741-238X |
| Popis: | Intensive postremission chemotherapy has produced disease-free survival comparable to that of bone marrow transplantation in patients with acute myelogenous leukemia (AML), but its efficacy was unknown in Taiwan. We assessed the efficacy of intensive postremission chemotherapy, consisting of high-dose arabinoside-C (HiDAC) with or without transplantation of peripheral blood stem cells, in 33 AML patients from a single institute in Taiwan. Toxic reactions, treatment outcome, prognostic factors, and the size of the peripheral blood stem-cell harvest after HiDAC were analyzed. After a median follow-up of 21 months, 18 patients remained in continuous complete remission. The actuarial leukemia-free survival at 4 years was 51%. Relapse occurred in 12 patients, at a median of 12 months after initial diagnosis. All 6 patients with acute promyelocytic leukemia remained disease free after HiDAC therapy. Age, sex, and number of remission-induction or intensive consolidation chemotherapy courses had no effect on the risk of relapse. Intensive postremission chemotherapy can effectively prolong the duration of remission in young ( |
| Databáze: | OpenAIRE |
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