A mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease

Autor:	Daniel P. Heruth, Pramod B. Mahajan, Jianping Zhou, Mukut Sharma, Yuexu Jiang, Ram Sharma, Lakshmi Priya, Tarak Srivastava, Uri Alon, Trupti Joshi, Madhulika Sharma, Virginia J. Savin, Mohammed Farhan Ali, Gregory B. Vanden Heuvel, Robert E. Garola, Varun C. Boinpelly, Mohammad H. Rezaiekhaligh, Ellen T. McCarthy
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Science 030232 urology & nephrology Apoptosis 030204 cardiovascular system & hematology Systemic inflammation Kidney Article 03 medical and health sciences Mice 0302 clinical medicine Downregulation and upregulation Pregnancy Internal medicine Developmental biology Medicine Animals Birth Weight Interleukin 6 Multidisciplinary biology business.industry Interleukin-6 Cell Cycle Organ Size Blot Mice Inbred C57BL Endocrinology medicine.anatomical_structure CpG site Animals Newborn Nephrology Prenatal Exposure Delayed Effects Podocin biology.protein Female medicine.symptom business
Zdroj:	Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
ISSN:	2045-2322
Popis:	Systemic inflammation in pregnant obese women is associated with 1.5- to 2-fold increase in serum Interleukin-6 (IL-6) and newborns with lower kidney/body weight ratio but the role of IL-6 in increased susceptibility to chronic kidney (CKD) in adult progeny is not known. Since IL-6 crosses the placental barrier, we administered recombinant IL-6 (10 pg/g) to pregnant mice starting at mid-gestation yielded newborns with lower body (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76d2df2170076088e9c2bde990415db https://pubmed.ncbi.nlm.nih.gov/34168254 Zobrazit plný text záznamu Plný text ve formátu PDF