Relationship Between Optic Nerve Head Drusen Volume and Structural and Functional Optic Nerve Damage
| Autor: | Jeffrey M. Liebmann, Stephanie Muylaert, Alon Skaat, Rudrani Banik, Robert Ritch, Rafael Furlanetto, Rachel S. Mogil, Sung Chul Park, Camila Netto |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity Adolescent genetic structures Optic Disk Visual Acuity Nerve fiber layer Glaucoma Drusen Young Adult 03 medical and health sciences chemistry.chemical_compound Imaging Three-Dimensional 0302 clinical medicine Optical coherence tomography Ophthalmology medicine Humans Aged medicine.diagnostic_test Optic Disk Drusen business.industry Retinal Middle Aged medicine.disease eye diseases Visual field medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Optic nerve Visual Field Tests Female sense organs Visual Fields medicine.symptom business Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | Journal of Glaucoma. 26:1095-1100 |
| ISSN: | 1057-0829 |
| DOI: | 10.1097/ijg.0000000000000783 |
| Popis: | PURPOSE The purpose of this study is to assess the relationships between optic nerve head drusen (ONHD) volume, retinal nerve fiber layer (RNFL) thickness and visual field (VF) loss. METHODS Patients with ONHD and no other ocular or systemic conditions that can affect RNFL or VF were enrolled. Serial enhanced depth imaging (EDI) optical coherence tomography (OCT) B-scans of the optic nerve head (interval between scans, ~30 μm) were obtained from each participant. ONHD volume was calculated for each eye by delineating the ONHD masses in each OCT B-scan using 3-dimensional reconstruction software. RESULTS A total of 47 eyes (28 patients) with ONHD were included (mean age, 57±16 y). ONHD volume varied considerably [0.265±0.227 (range, 0.005 to 0.855)] mm. Linear and quadratic regression analyses demonstrated that ONHD volume is significantly associated with both global average RNFL thickness (linear R=0.531, quadratic R=0.557; P |
| Databáze: | OpenAIRE |
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