Basal Chromogranin a and Gastrin Concentrations in Circulation Correlate to Endocrine Cell Proliferation in Type-A Gastritis
| Autor: | K Borch, M Stridsberg, P Burman, J F Rehfeld |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Gastritis
Atrophic Male endocrine system medicine.medical_specialty Atrophic gastritis Biopsy Enteroendocrine cell Carcinoid Tumor Gastroenterology Stomach Neoplasms Internal medicine Anemia Pernicious Gastrins Chromogranins Enterochromaffin Cells medicine Humans Antrum Aged Gastrin Hyperplasia biology business.industry Stomach Chromogranin A medicine.disease digestive system diseases Somatostatin Endocrinology medicine.anatomical_structure Gastric Mucosa biology.protein Female Gastritis medicine.symptom business |
| Zdroj: | Scandinavian Journal of Gastroenterology. 32:198-202 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529709000194 |
| Popis: | It is not known whether plasma chromogranin analysis could be a complement to histology for detection and grading of gastric fundic mucosal endocrine cell proliferation in hypergastrinemic (type-A) atrophic gastritis.Gastric biopsy sections (body and antrum) from 43 patients with type-A gastritis (9 with gastric carcinoid) were examined for density and micronodules of argyrophil endocrine cells. Fasting blood samples were analyzed for chromogranin A and B, gastrin, and somatostatin.All patients with carcinoid and 17 of the 34 without carcinoid had micronodules in the gastric fundic mucosa. The median plasma chromogranin A concentration was 5.7 (3.5-40.0) nmol/l in patients with carcinoid, 4.5 (3.0-9.5) nmol/l in patients with micronodules, and 3.7 (0.8-6.0) nmol/l in patients without micronodules. Overall, chromogranin A concentrations correlated to endocrine cell densities in the fundic mucosa (r = 0.64, P0.001) and to gastrin concentrations (r = 0.71, P0.001). Plasma somatostatin and chromogranin B concentrations did not differ significantly between the groups.In type-A gastritis, analysis of plasma chromogranin A may be a useful complement to histology in estimating the endocrine cell mass. Moreover, subclinical type-A gastritis may be a source of error when chromogranin A analysis is used in the search for neuroendocrine neoplasia. |
| Databáze: | OpenAIRE |
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