Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Autor: Anne Tjønneland, Christina Bamia, Aurelio Barricarte, Laure Dossus, Petra H.M. Peeters, Marc J. Gunter, Sabine Westhpal, Antonia Trichopoulou, Sabina Rinaldi, Ruth C. Travis, Veronika Fedirko, Fränzel J.B. Van Duijnhoven, J. Ramón Quirós, Kay-Tee Khaw, Philippos Orfanos, Rudolf Kaaks, Krasimira Aleksandrova, Richard Palmqvist, Neil Murphy, Esther Molina-Montes, Eric J. Duell, Eugene Jansen, Jytte Halkjær, Nicholas J. Wareham, Tobias Pischon, Mazda Jenab, Antoine Racine, María Dolores Chirlaque, Domenico Palli, Claudia Agnoli, Miren Dorronsoro, Pietro Ferrari, Heiner Boeing, Kim Overvad, Rosario Tumino, Elio Riboli, Ingrid Ljuslinder, Marie-Christine Boutron-Ruault, Salvatore Panico, Annekatrin Lukanova, H. Bas Bueno-de-Mesquita, Isabelle Romieu, Paolo Vineis
Přispěvatelé: Aleksandrova, K, Jenab, M, Bueno de Mesquita, Hb, Fedirko, V, Kaaks, R, Lukanova, A, van Duijnhoven, Fj, Jansen, E, Rinaldi, S, Romieu, I, Ferrari, P, Murphy, N, Gunter, Mj, Riboli, E, Westhpal, S, Overvad, K, Tj?nneland, A, Halkj?r, J, Boutron Ruault, Mc, Dossus, L, Racine, A, Trichopoulou, A, Bamia, C, Orfanos, P, Agnoli, C, Palli, D, Panico, Salvatore, Tumino, R, Vineis, P, Peeters, Ph, Duell, Ej, Molina Montes, E, Quir?s, Jr, Dorronsoro, M, Chirlaque, Md, Barricarte, A, Ljuslinder, I, Palmqvist, R, Travis, Rc, Khaw, Kt, Wareham, N, Pischon, T, Boeing, H.
Rok vydání: 2013
Předmět:
Oncology
Male
Nutrition and Disease
multiple imputation
Epidemiology
hdl-cholesterol
Rate ratio
adipose-tissue
Body Mass Index
chemistry.chemical_compound
c-reactive protein
Risk Factors
Voeding en Ziekte
plasma adiponectin
oxidative stress
Prospective Studies
Prospective cohort study
Incidence
density-lipoprotein cholesterol
Middle Aged
Prognosis
European Prospective Investigation into Cancer and Nutrition
Europe
C-Reactive Protein
Biomarker (medicine)
Female
Colorectal Neoplasms
Metabolic Networks and Pathways
medicine.medical_specialty
binding-proteins
insulin-resistance
soluble leptin receptor
Adipokines
Internal medicine
medicine
Biomarkers
Tumor
Humans
Triglycerides
VLAG
Aged
Glycated Hemoglobin
Inflammation
Leptin receptor
Adiponectin
business.industry
Case-control study
Endocrinology
Logistic Models
chemistry
Socioeconomic Factors
Case-Control Studies
Glycated hemoglobin
business
Zdroj: European Journal of Epidemiology, 29(4), 261-275
European Journal of Epidemiology 29 (2014) 4
Aleksandrova, K, Jenab, M, Bueno-de-Mesquita, H B, Fedirko, V, Kaaks, R, Lukanova, A, van Duijnhoven, F J B, Jansen, E, Rinaldi, S, Romieu, I, Ferrari, P, Murphy, N, Gunter, M J, Riboli, E, Westhpal, S, Overvad, K, Tjønneland, A, Halkjær, J, Boutron-Ruault, M-C, Dossus, L, Racine, A, Trichopoulou, A, Bamia, C, Orfanos, P, Agnoli, C, Palli, D, Panico, S, Tumino, R, Vineis, P, Peeters, P H, Duell, E J, Molina-Montes, E, Quirós, J R, Dorronsoro, M, Chirlaque, M-D, Barricarte, A, Ljuslinder, I, Palmqvist, R, Travis, R C, Khaw, K-T, Wareham, N, Pischon, T & Boeing, H 2014, ' Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer : results from the European Prospective Investigation into Cancer and Nutrition (EPIC) ', European Journal of Epidemiology, vol. 29, no. 4, pp. 261-75 . https://doi.org/10.1007/s10654-014-9901-8
ISSN: 1573-7284
0393-2990
Popis: A number of biomarkers of inflammatory and metabolic pathways are individually related to higher risk of colorectal cancer (CRC); however, the association between biomarker patterns and CRC incidence has not been previously evaluated. Our study investigates the association of biomarker patterns with CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). During median follow-up time of 7.0 (3.7-9.4) years, 1,260 incident CRC cases occurred and were matched to 1,260 controls using risk-set sampling. Pre-diagnostic measurements of C-peptide, glycated hemoglobin, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), reactive oxygen metabolites (ROM), insulin-like growth factor 1, adiponectin, leptin and soluble leptin receptor (sOB-R) were used to derive biomarker patterns from principal component analysis (PCA). The relation with CRC incidence was assessed using conditional logistic regression models. We identified four biomarker patterns 'HDL-C/Adiponectin fractions', 'ROM/CRP', 'TG/C-peptide' and 'leptin/sOB-R' to explain 60% of the overall biomarker variance. In multi-variable-adjusted logistic regression, the 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' patterns were associated with CRC risk [for the highest quartile vs the lowest, incidence rate ratio (IRR) = 0.69, 95% CI 0.51-0.93, P-trend = 0.01; IRR = 1.70, 95% CI 1.30-2.23, P-trend = 0.002; and IRR = 0.79, 95% CI 0.58-1.07; P-trend = 0.05, respectively]. In contrast, the 'TG/C-peptide' pattern was not associated with CRC risk (IRR = 0.75, 95% CI 0.56-1.00, P-trend = 0.24). After cases within the first 2 follow-up years were excluded, the 'ROM/CRP' pattern was no longer associated with CRC risk, suggesting potential influence of preclinical disease on these associations. By application of PCA, the study identified 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' as biomarker patterns representing potentially important pathways for CRC development. © Springer Science+Business Media 2014.
Databáze: OpenAIRE
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