Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway

Autor:	Jing Li, Lugen Zuo, Zhijun Geng, Qingqing Li, Yang Cheng, Zi Yang, Ruohan Shi, Yueqing Zhou, Wenhu Nie, Yueyue Wang, Xiaofeng Zhang, Sitang Ge, Xue Song, Jianguo Hu
Rok vydání:	2022
Předmět:	Inflammation Glycogen Synthase Kinase 3 beta Intracellular Signaling Peptides and Proteins Cell Biology General Medicine Colitis Interleukin-10 Mice Axin Protein Crohn Disease Adipocytes Animals Humans Mesentery
Zdroj:	Cell proliferation. 55(10)
ISSN:	1365-2184
Popis:	Crohn's disease (CD) mesenteric adipose tissue (MAT) inflammation affects enteritis through the interaction between the mesentery and intestine, and we previously found that poorly differentiated mesenteric adipocytes were related to its inflammatory features. Pygopus2 (Pygo2) is a key negative regulator of adipocyte differentiation. We aimed to determine whether Pygo2 participates in CD mesenteric lesions and whether Pygo2 knockdown would be beneficial in a CD model (Il-10Pygo2 expression in MAT from control and CD patients and Il-10Pygo2 expression was increased in MAT from CD patients and Il-10The increase in Pygo2 may be related to mesenteric adipocyte poor differentiation and inflammatory features of CD, and Pygo2 inhibition could alleviate CD-like colitis by improving mesenteric lesions by regulating the Axin2/GSK3β pathway.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c766560fe99626aee865deeae9ecf559 https://pubmed.ncbi.nlm.nih.gov/35707871 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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