Validation of Raised Cord Blood Interleukin-16 in Perinatal Asphyxia and Neonatal Hypoxic-Ischaemic Encephalopathy in the BiHiVE2 Cohort
| Autor: | Marc Paul O'Sullivan, Boubou Hallberg, Geraldine B. Boylan, Klaudia M Sikora, Mikael Finder, Deirdre Twomey, Caroline Ahearne, Deirdre M. Murray |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Encephalopathy Umbilical cord Cohort Studies 03 medical and health sciences 0302 clinical medicine Blood serum Developmental Neuroscience 030225 pediatrics medicine Humans Inflammation Asphyxia Neonatorum Interleukin-16 Obstetrics business.industry Infant Newborn Infant Fetal Blood medicine.disease Perinatal asphyxia medicine.anatomical_structure Neurology Cord blood Hypoxia-Ischemia Brain Cohort Gestation Biomarker (medicine) business 030217 neurology & neurosurgery |
| Zdroj: | Developmental Neuroscience. 40:271-277 |
| ISSN: | 1421-9859 0378-5866 |
| Popis: | The role of inflammation is an important factor in the progression of hypoxic-ischaemic encephalopathy (HIE). We have previously shown that interleukin-16 (IL-16) is increased in infants with moderate and severe HIE and relates to poor neurodevelopmental outcomes. We aimed to validate IL-16 as a cord blood-based biomarker for HIE and to examine its relationship to long-term outcomes. The study sample consisted of 105 full-term infants who experienced perinatal asphyxia (PA) (with and without an encephalopathy) along with healthy, gestational age-matched newborn controls. Umbilical cord blood serum was processed and biobanked at delivery. Infants were assigned a modified Sarnat score at 24 h. Analysis of IL-16 cytokine cord blood levels was performed using the sandwich-based enzyme-linked immunosorbent assay (ELISA) technique. Cord blood-based IL-16 was increased in infants with PA and HIE relative to controls (p = 0.025). IL-16 was also increased in the HIE group relative to controls (p = 0.042). There was no significant difference in IL-16 across grades of HIE or in those with abnormal outcomes at 2 years of age. This study validates findings that cord blood-based IL-16 levels are increased in infants with PA, including those who go on to develop HIE. |
| Databáze: | OpenAIRE |
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