A comparison between the effects of metformin andN-acetyl cysteine (NAC) on some metabolic and endocrine characteristics of women with polycystic ovary syndrome
| Autor: | Narges Sheikhansari, Forough Javanmanesh, Maryam Kashanian, Maryam Rahimi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Double-Blind Method Internal medicine medicine Humans Hypoglycemic Agents Insulin Endocrine system 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry nutritional and metabolic diseases Obstetrics and Gynecology Free Radical Scavengers Lipid Metabolism medicine.disease Polycystic ovary Metformin Acetylcysteine Female Lipid profile business Body mass index Homeostasis Polycystic Ovary Syndrome medicine.drug |
| Zdroj: | Gynecological Endocrinology. 32:285-289 |
| ISSN: | 1473-0766 0951-3590 |
| DOI: | 10.3109/09513590.2015.1115974 |
| Popis: | To compare N-acetyl cysteine (NAC) and metformin on polycystic ovary syndrome (PCOS).Study was performed as a randomized double-blind clinical trial on women with diagnosis of PCOS without additional complications. In one group, oral NAC 600 mg, three times a day and in the other group, 500 mg oral metformin, three times a day were prescribed. Duration of treatment was 24 weeks, and after finishing this period of treatment, fasting blood glucose (FBS) and insulin, lipid profile and Homeostasis Model Assessment (HOMA) index were measured (all the blood samples were taken while fasting) and were compared in the two groups.Forty-six women in NAC group and 48 women in metformin group finished the study. The two groups did not show significant difference according to age, body mass index (BMI) of more than 30; mean BMI, AUB, FBS, fasting blood insulin, lipid profile and HOMA index before treatment. After 24 weeks of treatment; BMI30 [17 (35.4%) versus 7 (15.2%), p = 0.033], mean BMI [(28.36 ± 2.27) versus (27.11 ± 3.55), p = 0.44], number of women with the complain of abnormal uterine bleeding (AUB) [24 (50%) versus 13 (28.3%), p = 0.037], FBS [(90.02 ± 6.24) versus (86.61 ± 7.81), p = 0.021], fasting insulin (10.40 ± 2.64 versus 8.89 ± 2.20, p = 0.004), HOMA Index (2.09 ± 0.69 versus 1.71 ± 0.45, p = 0.001), low density lipoprotein (LDL) (141.83 ± 26.98 versus 127.89 ± 28.70, p = 0.017) were less in NAC group. Triglyceride (TG) and total cholesterol did not show significant difference between the two groups after treatment. High-density lipoprotein (HDL) was higher in NAC group.NAC can improve lipid profile and fasting blood sugar (FBS) and fasting blood insulin better than metformin. |
| Databáze: | OpenAIRE |
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