Increased incidence of malignancy in patients with primary hyperparathyroidism
| Autor: | Muhammet Kocabaş, Mustafa Kulaksizoglu, Hatice Çalişkan Burgucu, Feridun Karakurt, Mustafa Can, Melia Karakose, İlker Çordan |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Primary hyperparathyroidism Malignancy Asymptomatic Article Breast cancer Internal medicine thyroid cancer cancer Humans Medicine Thyroid Neoplasms Stomach cancer Thyroid cancer Retrospective Studies business.industry Incidence Cancer Retrospective cohort study General Medicine Hyperparathyroidism Primary medicine.disease Calcium Female medicine.symptom business |
| Zdroj: | Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 |
| DOI: | 10.3906/sag-2012-18 |
| Popis: | Background/aim Primary hyperparathyroidism (PHPT) is a disease that is diagnosed more frequently and generally in the asymptomatic period, with widely available biochemical tests. Evidence suggesting an association between PHPT and malignancy risk is increasing. Clarification of this association will be useful in PHPT for malignancy screening and management of patients with PHPT. In this study, we aimed to investigate the frequency of cancer in PHPT patients. Materials and methods A total of 775 PHPT patients were included in the retrospective study. Demographic, clinical and laboratory data of the patients were evaluated retrospectively. Results Malignancy was detected in 128 (16.50%) of 775 PHPT patients (female/male: 625/150). The mean age at diagnosis of PHPT was 57.99 ± 10.86 years, and the mean age at diagnosis of malignancy was 57.46 ± 11.17 years. Of the 128 patients with malignancy, 53 (41.40%) were diagnosed in the same year as PHPT. In terms of malignancy types, 51 (6.50%) of 775 PHPT patients had thyroid cancer. Thyroid cancer was followed by breast cancer (2.30%) and stomach cancer (1%) in order of frequency. Conclusion We think that PHPT patients should be examined more carefully in terms of cancer risk, especially thyroid cancer. More comprehensive studies are needed to clarify the relationship between PHPT and cancer. |
| Databáze: | OpenAIRE |
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