Usefulness of ultrasensitive prostate-specific antigen assay for early detection of biochemical failure after radical prostatectomy
| Autor: | Hisashi Hasumi, Hiroji Uemura, Masafumi Nakamura, Kiyoshi Fujinami, Shinpei Sugiura, Yasuhide Miyoshi, Masahiro Yao, Yoshinobu Kubota |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Biochemical recurrence medicine.medical_specialty Urology Biochemical failure medicine.medical_treatment Salvage therapy Early detection urologic and male genital diseases Sensitivity and Specificity Prostate cancer Humans Medicine Treatment Failure Aged Retrospective Studies Prostatectomy Receiver operating characteristic business.industry Prostatic Neoplasms Prostate-Specific Antigen Prognosis medicine.disease Early Diagnosis Neoplasm Recurrence Local business Nadir (topography) |
| Zdroj: | International Journal of Urology. 12:1050-1054 |
| ISSN: | 1442-2042 0919-8172 |
| DOI: | 10.1111/j.1442-2042.2005.01202.x |
| Popis: | Background: In order to assess whether the prostate-specific antigen (PSA) nadir obtained with an ultrasensitive PSA assay can be used as a prognostic indicator for patients undergoing radical prostatectomy, we investigated it retrospectively. Methods: Between October 1997 and July 2003, 46 patients underwent radical prostatectomy for prostate cancer at our institution. None of them received preoperative treatment. Levels of PSA were measured with an ultrasensitive PSA assay every 1–3 months after prostatectomy. Biochemical recurrence was defined as a PSA level of 0.2 ng/mL or higher. Results: There was a significant difference in PSA nadir between the biochemical recurrence group and the no recurrence group (P < 0.001). The receiver operating characteristics (ROC) curve gave an optimal cut-off value for PSA nadir of 0.01 ng/mL, demonstrating a significant difference in biochemical recurrence after radical prostatectomy. No patient with a PSA nadir level |
| Databáze: | OpenAIRE |
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